Redefining the Role of ADAM17 in Renal Proximal Tubular Cells and Its Implications in an Obese Mouse Model of Pre-Diabetes.
ADAM17 Protein
/ genetics
Animals
Case-Control Studies
Collagen
/ metabolism
Diet, High-Fat
/ adverse effects
Disease Models, Animal
Galectin 3
Gene Knockout Techniques
Glucose Tolerance Test
Kidney Tubules, Proximal
/ metabolism
Mice
Mice, Obese
Obesity
/ chemically induced
Prediabetic State
/ etiology
Sodium-Glucose Transporter 2
/ metabolism
ADAM17
obesity
pre-diabetes
renal proximal tubular cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Dec 2021
03 Dec 2021
Historique:
received:
29
10
2021
revised:
26
11
2021
accepted:
30
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
21
12
2021
Statut:
epublish
Résumé
Acute and chronic kidney lesions induce an increase in A Disintegrin And Metalloproteinase domain 17 (ADAM17) that cleaves several transmembrane proteins related to inflammatory and fibrotic pathways. Our group has demonstrated that renal ADAM17 is upregulated in diabetic mice and its inhibition decreases renal inflammation and fibrosis. The purpose of the present study was to analyze how
Identifiants
pubmed: 34884897
pii: ijms222313093
doi: 10.3390/ijms222313093
pmc: PMC8657896
pii:
doi:
Substances chimiques
Galectin 3
0
Lgals3 protein, mouse
0
Slc5a2 protein, mouse
0
Sodium-Glucose Transporter 2
0
Collagen
9007-34-5
ADAM17 Protein
EC 3.4.24.86
Adam17 protein, mouse
EC 3.4.24.86
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Instituto de Salud Carlos III
ID : PI16/00620
Organisme : Instituto de Salud Carlos III
ID : PI17/00257
Organisme : Instituto de Salud Carlos III
ID : RD16/0009/0013
Organisme : Instituto de Salud Carlos III
ID : RD21/0005
Organisme : Government of Catalonia
ID : STL008/18/00018
Organisme : Instituto de Salud Carlos III
ID : FI17/00025
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