Deciphering Promoter Hypermethylation of Genes Encoding for RASSF/Hippo Pathway Reveals the Poor Prognostic Factor of RASSF2 Gene Silencing in Colon Cancers.
RASSF/Hippo pathway
colon cancers
molecular biomarker
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Nov 2021
26 Nov 2021
Historique:
received:
19
10
2021
revised:
20
11
2021
accepted:
23
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
The aims of this study were to assess the frequency of promoter hypermethylation of the genes encoding the Ras associated domain family (RASSF)/Hippo pathway, as well as the impact on overall (OS) and progression-free survival (PFS) in a single-center retrospective cohort of 229 patients operated on for colon cancers. Hypermethylation status was investigated by methylation-specific PCR on the promoters of the
Identifiants
pubmed: 34885067
pii: cancers13235957
doi: 10.3390/cancers13235957
pmc: PMC8656858
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : APRI from the at the Caen University Hospital center
ID : grant number 2018
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