Hypoxia and Its Influence on Radiotherapy Response of HPV-Positive and HPV-Negative Head and Neck Cancer.
head and neck squamous cell carcinoma
human papillomavirus
hypoxia
radiotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
26 Nov 2021
26 Nov 2021
Historique:
received:
30
10
2021
revised:
15
11
2021
accepted:
19
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
Head and neck squamous cancers are a heterogeneous group of cancers that arise from the upper aerodigestive tract. Etiologically, these tumors are linked to alcohol/tobacco abuse and infections with high-risk human papillomavirus (HPV). HPV-positive HNSCCs are characterized by a different biology and also demonstrate better therapy response and survival compared to alcohol/tobacco-related HNSCCs. Despite this advantageous therapy response and the clear biological differences, all locally advanced HNSCCs are treated with the same chemo-radiotherapy schedules. Although we have a better understanding of the biology of both groups of HNSCC, the biological factors associated with the increased radiotherapy response are still unclear. Hypoxia, i.e., low oxygen levels because of an imbalance between oxygen demand and supply, is an important biological factor associated with radiotherapy response and has been linked with HPV infections. In this review, we discuss the effects of hypoxia on radiotherapy response, on the tumor biology, and the tumor microenvironment of HPV-positive and HPV-negative HNSCCs by pointing out the differences between these two tumor types. In addition, we provide an overview of the current strategies to detect and target hypoxia.
Identifiants
pubmed: 34885069
pii: cancers13235959
doi: 10.3390/cancers13235959
pmc: PMC8656584
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Research Foundation - Flanders
ID : 18B4122N
Organisme : Research Foundation - Flanders
ID : 1521019N
Organisme : Kom op tegen kanker
ID : NA
Organisme : KU Leuven Research Fund
ID : C24/17/073
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