DNA Methylation Analysis in Plasma Cell-Free DNA and Paired CTCs of NSCLC Patients before and after Osimertinib Treatment.
DNA methylation
NSCLC
cell-free DNA
circulating tumor cells
liquid biopsy
osimertinib
real-time MSP
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
27 Nov 2021
27 Nov 2021
Historique:
received:
21
10
2021
revised:
22
11
2021
accepted:
25
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
Osimertinib has been an effective second-line treatment in EGFR mutant NSCLC patients; however, resistance inevitably occurs. DNA methylation has been previously implicated in NSCLC progression and often in therapy resistance, however its distinct role in osimertinib resistance is not elucidated as yet. In the present study, we directly compared DNA methylation of nine selected genes (
Identifiants
pubmed: 34885084
pii: cancers13235974
doi: 10.3390/cancers13235974
pmc: PMC8656722
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stavros Niarchos Foundation
ID : 16785
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