Exploring Amantadine Derivatives as Urease Inhibitors: Molecular Docking and Structure-Activity Relationship (SAR) Studies.
Amantadine
/ analogs & derivatives
Catalytic Domain
/ drug effects
Enzyme Inhibitors
/ chemistry
Helicobacter Infections
/ drug therapy
Helicobacter pylori
/ drug effects
Humans
Hydrogen Bonding
/ drug effects
Kinetics
Molecular Docking Simulation
Molecular Structure
Structure-Activity Relationship
Thiourea
/ chemistry
Urease
/ antagonists & inhibitors
acyl/aroyl thioureas
enzyme inhibitory kinetics
molecular docking
synthesis
urease inhibitors
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
25
09
2021
revised:
21
11
2021
accepted:
22
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
12
2
2022
Statut:
epublish
Résumé
This article describes the design and synthesis of a series of novel amantadine-thiourea conjugates (
Identifiants
pubmed: 34885728
pii: molecules26237150
doi: 10.3390/molecules26237150
pmc: PMC8658948
pii:
doi:
Substances chimiques
Enzyme Inhibitors
0
Amantadine
BF4C9Z1J53
Urease
EC 3.5.1.5
Thiourea
GYV9AM2QAG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Taif University
ID : TURSP-2020/81
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