Preliminary Study of New Gallium-68 Radiolabeled Peptide Targeting NRP-1 to Detect Brain Metastases by Positron Emission Tomography.
Animals
Brain Neoplasms
/ diagnosis
Cell Line, Tumor
Cell Proliferation
Cell Tracking
Cerebellum
/ diagnostic imaging
Female
Gallium Radioisotopes
/ chemistry
Human Umbilical Vein Endothelial Cells
/ metabolism
Humans
Neuropilin-1
/ metabolism
Peptides
/ chemical synthesis
Positron-Emission Tomography
Protein Binding
Radiopharmaceuticals
/ chemical synthesis
Rats, Nude
Recombinant Proteins
/ metabolism
Surface Plasmon Resonance
Water
/ chemistry
NRP-1
brain metastases
fluorescence
peptide
radiolabeling
targeting
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
30 Nov 2021
30 Nov 2021
Historique:
received:
08
10
2021
revised:
11
11
2021
accepted:
23
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Due to their very poor prognosis and a fatal outcome, secondary brain tumors are one of the biggest challenges in oncology today. From the point of view of the early diagnosis of these brain micro- and macro-tumors, the sensitivity and specificity of the diagnostic tools constitute an obstacle. Molecular imaging, such as Positron Emission Tomography (PET), is a promising technique but remains limited in the search for cerebral localizations, given the commercially available radiotracers. Indeed, the [
Identifiants
pubmed: 34885871
pii: molecules26237273
doi: 10.3390/molecules26237273
pmc: PMC8659110
pii:
doi:
Substances chimiques
Gallium Radioisotopes
0
Peptides
0
Radiopharmaceuticals
0
Recombinant Proteins
0
Water
059QF0KO0R
Neuropilin-1
144713-63-3
Gallium-68
98B30EPP5S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Great East European Regional Development Fund (ERDF) and Contrat Plan Etat-Région (CPER) from French government, Great East Regional Council and Lorraine Université d'Excellence (LUE)
ID : 000
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