Copper-Catalyzed Ring-Opening Reactions of Alkyl Aziridines with B
DFT study
aminoboronates
aziridines
copper catalysis
diboron reagents
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
06 Dec 2021
06 Dec 2021
Historique:
received:
14
10
2021
revised:
23
11
2021
accepted:
03
12
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
The possibility to form new C-B bonds with aziridines using diboron derivatives continues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individuation of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B
Identifiants
pubmed: 34885983
pii: molecules26237399
doi: 10.3390/molecules26237399
pmc: PMC8659106
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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