dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project.
Journal
Human genome variation
ISSN: 2054-345X
Titre abrégé: Hum Genome Var
Pays: England
ID NLM: 101652445
Informations de publication
Date de publication:
10 Dec 2021
10 Dec 2021
Historique:
received:
05
07
2021
accepted:
08
09
2021
revised:
08
09
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
To reveal gene-environment interactions underlying common diseases and estimate the risk for common diseases, the Tohoku Medical Megabank (TMM) project has conducted prospective cohort studies and genomic and multiomics analyses. To establish an integrated biobank, we developed an integrated database called "dbTMM" that incorporates both the individual cohort/clinical data and the genome/multiomics data of 157,191 participants in the Tohoku Medical Megabank project. To our knowledge, dbTMM is the first database to store individual whole-genome data on a variant-by-variant basis as well as cohort/clinical data for over one hundred thousand participants in a prospective cohort study. dbTMM enables us to stratify our cohort by both genome-wide genetic factors and environmental factors, and it provides a research and development platform that enables prospective analysis of large-scale data from genome cohorts.
Identifiants
pubmed: 34887386
doi: 10.1038/s41439-021-00175-5
pii: 10.1038/s41439-021-00175-5
pmc: PMC8660797
doi:
Types de publication
Journal Article
Langues
eng
Pagination
44Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0105001,JP20km0105002,JP20km0405001
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : JP20km0105001,JP20km0105002,JP20km0405001
Investigateurs
Masayuki Yamamoto
(M)
Michiaki Abe
(M)
Yayoi Aizawa
(Y)
Yuichi Aoki
(Y)
Koichi Chida
(K)
Inaho Danjoh
(I)
Shinichi Egawa
(S)
Ai Eto
(A)
Takamitsu Funayama
(T)
Nobuo Fuse
(N)
Yohei Hamanaka
(Y)
Yuki Harada
(Y)
Hiroaki Hashizume
(H)
Shinichi Higuchi
(S)
Sachiko Hirano
(S)
Takumi Hirata
(T)
Masahiro Hiratsuka
(M)
Atsushi Hozawa
(A)
Kazuhiko Igarashi
(K)
Jin Inoue
(J)
Noriko Ishida
(N)
Naoto Ishii
(N)
Tadashi Ishii
(T)
Mami Ishikuro
(M)
Kiyoshi Ito
(K)
Sadayoshi Ito
(S)
Maiko Kageyama
(M)
Fumiki Katsuoka
(F)
Hiroshi Kawame
(H)
Junko Kawashima
(J)
Masahiro Kikuya
(M)
Kengo Kinoshita
(K)
Kazuyuki Kitatani
(K)
Tomomi Kiyama
(T)
Hideyasu Kiyomoto
(H)
Tomoko Kobayashi
(T)
Eiichi Kodama
(E)
Mana Kogure
(M)
Kaname Kojima
(K)
Sachie Koreeda
(S)
Seizo Koshiba
(S)
Shihoko Koyama
(S)
Hisaaki Kudo
(H)
Kazuki Kumada
(K)
Shigeo Kure
(S)
Miho Kuriki
(M)
Shinichi Kuriyama
(S)
Yoko Kuroki
(Y)
Norihide Maikusa
(N)
Satoshi Makino
(S)
Hiroko Matsubara
(H)
Hiroyuki Matsui
(H)
Hirohito Metoki
(H)
Takahiro Mimori
(T)
Naoko Minegishi
(N)
Kazuharu Misawa
(K)
Masako Miyashita
(M)
Satoshi Mizuno
(S)
Hozumi Motohashi
(H)
Ikuko N Motoike
(IN)
Satoshi Nagaie
(S)
Masato Nagai
(M)
Fuji Nagami
(F)
Masao Nagasaki
(M)
Sachiko Nagase
(S)
Naoki Nakamura
(N)
Tomohiro Nakamura
(T)
Naoki Nakaya
(N)
Keiko Nakayama
(K)
Akira Narita
(A)
Ichiko Nishijima
(I)
Takahiro Nobukuni
(T)
Kotaro Nochioka
(K)
Taku Obara
(T)
Soichi Ogishima
(S)
Noriaki Ohuchi
(N)
Gervais Olivier
(G)
Noriko Osumi
(N)
Hiroshi Otsu
(H)
Akihito Otsuki
(A)
Daisuke Saigusa
(D)
Sakae Saito
(S)
Tomo Saito
(T)
Masaki Sakaida
(M)
Mika Sakurai-Yageta
(M)
Yuki Sato
(Y)
Yukuto Sato
(Y)
Atsushi Sekiguchi
(A)
Chen-Yang Shen
(CY)
Tomoko F Shibata
(TF)
Ritsuko Shimizu
(R)
Kazuro Shimokawa
(K)
Matsuyuki Shirota
(M)
Junichi Sugawara
(J)
Kichiya Suzuki
(K)
Yoichi Suzuki
(Y)
Shu Tadaka
(S)
Makiko Taira
(M)
Takako Takai-Igarashi
(T)
Yuji Takano
(Y)
Yasuyuki Taki
(Y)
Gen Tamiya
(G)
Osamu Tanabe
(O)
Hiroshi Tanaka
(H)
Yukari Tanaka
(Y)
Shunsuke Teraguchi
(S)
Takahiro Terakawa
(T)
Teiji Tominaga
(T)
Hiroaki Tomita
(H)
Akito Tsuboi
(A)
Naho Tsuchiya
(N)
Ichiro Tsuji
(I)
Masao Ueki
(M)
Akira Uruno
(A)
Nobuo Yaegashi
(N)
Junya Yamagishi
(J)
Yumi Yamaguchi-Kabata
(Y)
Chizuru Yamanaka
(C)
Riu Yamashita
(R)
Jun Yasuda
(J)
Junji Yokozawa
(J)
Kazunori Waki
(K)
Makoto Sasaki
(M)
Junko Akai
(J)
Ryujin Endo
(R)
Akimune Fukushima
(A)
Ryohei Furukawa
(R)
Tsuyoshi Hachiya
(T)
Kouhei Hashizume
(K)
Jiro Hitomi
(J)
Yasushi Ishigaki
(Y)
Shohei Komaki
(S)
Yuka Kotozaki
(Y)
Takahiro Mikami
(T)
Motoyuki Nakamura
(M)
Naoyuki Nishiya
(N)
Satoshi Nishizuka
(S)
Yoko Nomura
(Y)
Kuniaki Ogasawara
(K)
Hideki Ohmomo
(H)
Shinichi Omama
(S)
Ryo Otomo
(R)
Kotaro Otsuka
(K)
Kotaro Oyama
(K)
Kiyomi Sakata
(K)
Ryohei Sasaki
(R)
Mamoru Satoh
(M)
Namie Sato
(N)
Atsushi Shimizu
(A)
Yu Shiwa
(Y)
Yoichi Sutoh
(Y)
Nobuyuki Takanashi
(N)
Noriko Takebe
(N)
Fumitaka Tanaka
(F)
Ryoichi Tanaka
(R)
Kozo Tanno
(K)
Tomoharu Tokutomi
(T)
Kayono Yamamoto
(K)
Fumio Yamashita
(F)
Informations de copyright
© 2021. The Author(s).
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