Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 12 2021
09 12 2021
Historique:
received:
08
08
2021
accepted:
16
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
22
12
2021
Statut:
epublish
Résumé
A characteristic clinical feature of COVID-19 is the frequent incidence of microvascular thrombosis. In fact, COVID-19 autopsy reports have shown widespread thrombotic microangiopathy characterized by extensive diffuse microthrombi within peripheral capillaries and arterioles in lungs, hearts, and other organs, resulting in multiorgan failure. However, the underlying process of COVID-19-associated microvascular thrombosis remains elusive due to the lack of tools to statistically examine platelet aggregation (i.e., the initiation of microthrombus formation) in detail. Here we report the landscape of circulating platelet aggregates in COVID-19 obtained by massive single-cell image-based profiling and temporal monitoring of the blood of COVID-19 patients (n = 110). Surprisingly, our analysis of the big image data shows the anomalous presence of excessive platelet aggregates in nearly 90% of all COVID-19 patients. Furthermore, results indicate strong links between the concentration of platelet aggregates and the severity, mortality, respiratory condition, and vascular endothelial dysfunction level of COVID-19 patients.
Identifiants
pubmed: 34887400
doi: 10.1038/s41467-021-27378-2
pii: 10.1038/s41467-021-27378-2
pmc: PMC8660840
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7135Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM130825
Pays : United States
Informations de copyright
© 2021. The Author(s).
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