The Dynamics of Aerotaxis in a Simple Eukaryotic Model.

Dictyostelium G-protein aerotaxis catalase collective cell migration hydrogen peroxide oxidative stress

Journal

Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250

Informations de publication

Date de publication:
2021
Historique:
received: 04 06 2021
accepted: 13 10 2021
entrez: 10 12 2021
pubmed: 11 12 2021
medline: 11 12 2021
Statut: epublish

Résumé

In aerobic organisms, oxygen is essential for efficient energy production, and it acts as the last acceptor of the mitochondrial electron transport chain and as regulator of gene expression. However, excessive oxygen can lead to production of deleterious reactive oxygen species. Therefore, the directed migration of single cells or cell clumps from hypoxic areas toward a region of optimal oxygen concentration, named aerotaxis, can be considered an adaptive mechanism that plays a major role in biological and pathological processes. One relevant example is the development of O

Identifiants

pubmed: 34888305
doi: 10.3389/fcell.2021.720623
pmc: PMC8650612
doi:

Types de publication

Journal Article

Langues

eng

Pagination

720623

Informations de copyright

Copyright © 2021 Biondo, Panuzzo, Ali, Bozzaro, Osella, Bracco and Pergolizzi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Marta Biondo (M)

Department of Physics, INFN, University of Turin, Turin, Italy.

Cristina Panuzzo (C)

Department of Clinical and Biological Science, University of Turin, Turin, Italy.

Shahzad M Ali (SM)

Department of Clinical and Biological Science, University of Turin, Turin, Italy.

Salvatore Bozzaro (S)

Department of Clinical and Biological Science, University of Turin, Turin, Italy.

Matteo Osella (M)

Department of Physics, INFN, University of Turin, Turin, Italy.

Enrico Bracco (E)

Department of Oncology, University of Turin, Turin, Italy.

Barbara Pergolizzi (B)

Department of Clinical and Biological Science, University of Turin, Turin, Italy.

Classifications MeSH