Deregulation of Transcription Factor Networks Driving Cell Plasticity and Metastasis in Pancreatic Cancer.
ADM—acinar to ductal metaplasia
PDAC—pancreatic ductal adenocarcinoma
PanIN—pancreatic intraepithelial neoplasia
cellular plasticity
development
epigenetics (chromatin remodelling)
transcription factors (TFs)
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
08
2021
accepted:
27
10
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
11
12
2021
Statut:
epublish
Résumé
Pancreatic cancer is a very aggressive disease with 5-year survival rates of less than 10%. The constantly increasing incidence and stagnant patient outcomes despite changes in treatment regimens emphasize the requirement of a better understanding of the disease mechanisms. Challenges in treating pancreatic cancer include diagnosis at already progressed disease states due to the lack of early detection methods, rapid acquisition of therapy resistance, and high metastatic competence. Pancreatic ductal adenocarcinoma, the most prevalent type of pancreatic cancer, frequently shows dominant-active mutations in
Identifiants
pubmed: 34888306
doi: 10.3389/fcell.2021.753456
pii: 753456
pmc: PMC8650502
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
753456Informations de copyright
Copyright © 2021 van Roey, Brabletz, Stemmler and Armstark.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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