Risk of postpartum haemorrhage is associated with ethnicity: A cohort study of 981 801 births in England.


Journal

BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741

Informations de publication

Date de publication:
07 2022
Historique:
revised: 09 11 2021
received: 05 07 2021
accepted: 24 11 2021
pubmed: 11 12 2021
medline: 22 6 2022
entrez: 10 12 2021
Statut: ppublish

Résumé

To determine the association between ethnic group and risk of postpartum haemorrhage in women giving birth. Cohort study. Maternity units in England. A total of 981 801 records of births between 1 April 2015 and 31 March 2017 in a national clinical database. Multivariable logistic regression analyses with multiple imputation to account for missing data and robust standard errors to account for clustering within hospitals. Postpartum haemorrhage of ≥1500 ml (PPH). A total of 28 268 (2.9%) births were complicated by PPH. Risks were higher in women from black (3.9%) and other (3.5%) ethnic backgrounds. Following adjustment for maternal and fetal characteristics, and care at birth, there was evidence of an increased risk of PPH in women from all ethnic minority groups, with the largest increase seen in black women (adjusted OR 1.54, 95% CI 1.45-1.63). The increase in risk was robust to sensitivity analyses, which included changing the outcome to PPH of ≥3000 ml. In England, women from ethnic minority backgrounds have an increased risk of PPH, when maternal, fetal and birth characteristics are taken into account. Factors contributing to this increased risk need further investigation. Perinatal care for women from ethnic minority backgrounds should focus on preventative measures to optimise maternal outcomes. Women with an ethnic minority background giving birth in England have an increased risk of postpartum haemorrhage, even when characteristics of the mother, the baby and the care received are taken into account.

Identifiants

pubmed: 34889021
doi: 10.1111/1471-0528.17051
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1269-1277

Subventions

Organisme : Healthcare Quality Improvement Partnership

Informations de copyright

© 2021 John Wiley & Sons Ltd.

Références

Knight M, Bunch K, Tuffnell D, Shakespeare J, Kotnis R, Kenyon S, et al. Saving Lives, Improving Mothers' Care - Lessons Learned to Inform Maternity Care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2016-18. Oxford, UK: National Perinatal Epidemiology Unit, University of Oxford; 2021.
GBD 2015 Maternal Mortality Collaborators, Kassebaum NJ, Barber RM, Bhutta ZA, Dandona L, Gething PW, et al. Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1775-812.
Furuta M, Sandall J, Bick D. Women's perceptions and experiences of severe maternal morbidity-a synthesis of qualitative studies using a meta-ethnographic approach. Midwifery. 2013;30(2):158-69.
Eckerdal P, Kollia N, Löfblad J, Hellgren C, Karlsson L, Högberg U, et al. Delineating the association between heavy postpartum haemorrhage and postpartum depression. PLoS One. 2016;11(1):e0144274.
Thompson JF, Heal LJ, Roberts CL, Ellwood DA. Women's breastfeeding experiences following a significant primary postpartum haemorrhage: a multicentre cohort study. Int Breastfeed J. 2010;5(1):5.
Weeks A. The prevention and treatment of postpartum haemorrhage: what do we know, and where do we go to next? BJOG: Int J Obstet Gynaecol. 2015;122(2):202-10.
Salati JA, Leathersich SJ, Williams MJ, Cuthbert A, Tolosa JE. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Db Syst Rev. 2019;4(4):CD001808.
Shakur H, Roberts I, Fawole B, Chaudhri R, El-Sheikh M, Akintan A, et al. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial. Lancet. 2017;389:2105-16.
Nair M, Kurinczuk JJ, Knight M. Ethnic variations in severe maternal morbidity in the UK - a case control study. PLoS One. 2014;9(4):e95086.
Jardine J, Gurol-Urganci I, Harris T, Hawdon J, Pasupathy D, Meulen J, et al. Associations between ethnicity and admission to intensive care among women giving birth: a cohort study. BJOG: Int J Obstet Gynaecol. 2021.
Bryant AS, Seely EW, Cohen A, Lieberman E. Patterns of pregnancy-related hypertension in black and white women. Hypertens Pregnancy. 2009;24(3):281-90.
Gyamfi-Bannerman C, Srinivas SK, Wright JD, Goffman D, Siddiq Z, D’Alton ME, et al. Postpartum hemorrhage outcomes and race. Am J Obstet Gynecol. 2018;219(2):185.e1-185.e10.
Thurn L, Wikman A, Westgren M, Lindqvist P. Massive blood transfusion in relation to delivery: incidence, trends and risk factors: a population-based cohort study. BJOG: Int J Obstet Gynaecol. 2019;126(13):1577-86.
Mavrides E, Allard S, Chandraharan E, Collins P, Green L, Hunt B, et al. Prevention and management of postpartum haemorrhage. Bjog Int J Obstet Gynaecol. 2017;124(5):e106-49.
Chandraharan E, Krishna A. Diagnosis and management of postpartum haemorrhage. BMJ. 2017;358:j3875.
World Health Organization. WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage. Geneva, Switzerland: World Health Organization; 2012.
ONS. Provisional Births in England and Wales - Office for National Statistics [Internet]. London, UK: ONS; 2021. https://www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/livebirths/articles/provisionalbirthsinenglandandwales/2020#:~:text=Based%20on%20birth%20notification%20data,most%20recent%20peak%20in%202012. Accessed 21 March 2021.
NMPA Project Team. National Maternity and Perinatal Audit Clinical Report 2017: Revised Version. London, UK: Royal College of Obstetricians and Gynaecologists; 2018.
NMPA Project Team. National Maternity and Perinatal Audit: Clinical Report 2019 [Internet]. London, UK: Royal College of Obstetricians and Gynaecologists; 2019. https://maternityaudit.org.uk/FilesUploaded/NMPA%20Clinical%20Report%202019.pdf. Accessed 2 November 2020.
Patel A, Goudar SS, Geller SE, Kodkany BS, Edlavitch SA, Wagh K, et al. Drape estimation vs. visual assessment for estimating postpartum hemorrhage. Int J Gynecol Amp Obstetrics. 2006;93(3):220-4.
Bose P, Regan F, Paterson-Brown S. Improving the accuracy of estimated blood loss at obstetric haemorrhage using clinical reconstructions. BJOG: Int J Obstet Gynaecol. 2006;113(8):919-24.
Calvert C, Thomas SL, Ronsmans C, Wagner KS, Adler AJ, Filippi V. Identifying regional variation in the prevalence of postpartum haemorrhage: a systematic review and meta-analysis. PLoS One. 2012;7(7):e41114.
Flood MM, Pollock WE, McDonald SJ, Davey M-A. Monitoring postpartum haemorrhage in Australia: opportunities to improve reporting. Women Birth. 2018;31(2):89-95.
Meher S, Cuthbert A, Kirkham J, Williamson P, Abalos E, Aflaifel N, et al. Core outcome sets for prevention and treatment of postpartum haemorrhage: an international Delphi consensus study. BJOG: Int J Obstet Gynaecol. 2019;126(1):83-93.
NHS Digital. NHS Data Dictionary: Ethnic Category Code 2001 [Internet]. https://www.datadictionary.nhs.uk/data_dictionary/attributes/e/end/ethnic_category_code_2001_de.asp. Accessed 17 January 2020.
Jardine JE, Frémeaux A, Coe M, Urganci IG, Pasupathy D, Walker K. Validation of ethnicity in administrative hospital data in women giving birth in England: cohort study. BMJ Open. 2021;11(8):e051977.
World Health Organisation. International Statistical Classification of Diseases and Related Health Problems 10th Revision [Internet]. Geneva, Switzerland: World Health Organization; 2016. https://icd.who.int/browse10/2016/en. Accessed 1 November 2021.
Department for Communities and Local Government. The English Indices of Deprivation 2015 Statistical Release [Internet]. 2015. https://www.gov.uk/government/statistics/english-indices-of-deprivation-2015. Accessed 15 March 2021.
Williams RL. A Note on robust variance estimation for cluster-correlated data. Biometrics. 2000;56(2):645-6.
White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011;30(4):377-99.
Bartlett JW, Harel O, Carpenter JR. Asymptotically unbiased estimation of exposure odds ratios in complete records logistic regression. Am J Epidemiol. 2015;182(8):730-6.
Bryant AS, Worjoloh A, Caughey AB, Washington AE. Racial/ethnic disparities in obstetric outcomes and care: prevalence and determinants. Am J Obstet Gynecol. 2010;202(4):335-43.
Nair M, Kurinczuk JJ, Knight M. Establishing a national maternal morbidity outcome indicator in England: A population-based study using routine hospital data. PLoS One. 2016;11(4):e0153370.
Cheong-See F, Allotey J, Marlin N, Mol B, Schuit E, Riet G, et al. Prediction models in obstetrics: understanding the treatment paradox and potential solutions to the threat it poses. BJOG: Int J Obstet Gynaecol. 2016;123(7):1060-4.
Bell SF, Watkins A, John M, Macgillivray E, Kitchen TL, James D, et al. Incidence of postpartum haemorrhage defined by quantitative blood loss measurement: a national cohort. Bmc Pregnancy Childb. 2020;20(1):271.
Draper ES, Gallimore ID, Smith LK, Fenton AC, Kurinczuk JJ, Smith PW, et al. MBRRACE-UK Perinatal Mortality Surveillance Report, UK Perinatal Deaths for Births from January to December 2018. [Internet]. Leicester, UK: The Infant Mortality and Morbidity Studies, Department of Health Sciences, University of Leicester; 2020. https://www.npeu.ox.ac.uk/assets/downloads/mbrrace-uk/reports/perinatal-surveillance-report-2018/MBRRACE-UK_Perinatal_Surveillance_Report_2018_-_final_v2.pdf. Accessed 2 May 2021.
Lindquist A, Knight M, Kurinczuk JJ. Variation in severe maternal morbidity according to socioeconomic position: a UK national case-control study. BMJ Open. 2013;3(6):e002742.
Cookson R, Propper C, Asaria M, Raine R. Socio-economic inequalities in health care in England. Fisc Stud. 2016;37(3-4):371-403.
Moscelli G, Siciliani L, Gutacker N, Cookson R. Socioeconomic inequality of access to healthcare: does choice explain the gradient? J Health Econ. 2018;57:290-314.
Greenberg MB, Cheng YW, Hopkins LM, Stotland NE, Bryant AS, Caughey AB. Are there ethnic differences in the length of labor? Am J Obstet Gynecol. 2006;195(3):743-8.
Barton JC, Wiener HH, Acton RT, Adams PC, Eckfeldt JH, Gordeuk VR, et al. Prevalence of iron deficiency in 62,685 women of seven race/ethnicity groups: The HEIRS Study. PLoS One. 2020;15(4):e0232125.
Lee HJ, Norwitz ER, Shaw J. Contemporary management of fibroids in pregnancy. Rev Obstet Gynecol. 2010;3(1):20-7.
Henderson J, Gao H, Redshaw M. Experiencing maternity care: the care received and perceptions of women from different ethnic groups. BMC Pregnancy Childb. 2013;13(1):196.
Jomeen J, Redshaw M. Ethnic minority women's experience of maternity services in England. Ethnic Health. 2012;18(3):280-96.

Auteurs

Jennifer Jardine (J)

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Quality Improvement and Clinical Audit, Royal College of Obstetricians and Gynaecologists, London, UK.

Ipek Gurol-Urganci (I)

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Centre for Quality Improvement and Clinical Audit, Royal College of Obstetricians and Gynaecologists, London, UK.

Tina Harris (T)

Centre for Reproduction Research, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK.

Jane Hawdon (J)

Royal Free London NHS Foundation Trust, London, UK.

Dharmintra Pasupathy (D)

Department of Women and Children's Health, King's College London, London, UK.
Reproduction and Perinatal Centre, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.

Jan van der Meulen (J)

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.

Kate Walker (K)

Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Clinical Effectiveness Unit, Royal College of Surgeons, London, UK.

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