Understanding neutropenia secondary to intrinsic or iatrogenic immune dysregulation.
Chediak-Higashi Syndrome
/ complications
Female
Humans
Hyper-IgM Immunodeficiency Syndrome
/ complications
Iatrogenic Disease
/ epidemiology
Immune Checkpoint Inhibitors
/ adverse effects
Immunotherapy
/ adverse effects
Middle Aged
Neutropenia
/ etiology
Primary Immunodeficiency Diseases
/ complications
Journal
Hematology. American Society of Hematology. Education Program
ISSN: 1520-4383
Titre abrégé: Hematology Am Soc Hematol Educ Program
Pays: United States
ID NLM: 100890099
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
16
2
2022
Statut:
ppublish
Résumé
As a key member of the innate and adaptive immune response, neutrophils provide insights into the hematopoietic and inflammatory manifestations of inborn errors of immunity (IEI) and the consequences of immunotherapy. The facile recognition of IEI presenting with neutropenia provides an avenue for hematologists to facilitate early diagnosis and expedite biologically rationale care. Moreover, enhancing the understanding of the molecular mechanisms driving neutropenia in IEI-decreased bone marrow reserves, diminished egress from the bone marrow, and decreased survival-offers an opportunity to further dissect the pathophysiology driving neutropenia secondary to iatrogenic immune dysregulation, eg, immune checkpoint inhibitors and chimeric antigen receptor T-cell therapy.
Identifiants
pubmed: 34889406
pii: 482980
doi: 10.1182/hematology.2021000285
pmc: PMC8791120
doi:
Substances chimiques
Immune Checkpoint Inhibitors
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
504-513Informations de copyright
Copyright © 2021 by The American Society of Hematology.
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