Alkylverdazyls as a Source of Alkyl Radicals for Light-Triggered Cancer Cell Death.

Cell Death / drug effects Free Radicals / metabolism Humans MCF-7 Cells / drug effects Photochemotherapy / methods Photosensitizing Agents / pharmacology
alkylated verdazyls cancer cell death photolysis

Journal

Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791

Informations de publication

Date de publication:
03 01 2022
Historique:
pubmed: 11 12 2021
medline: 29 3 2022
entrez: 10 12 2021
Statut: ppublish

Résumé

Two alkylated verdazyl radicals (AlkVZs) were investigated as active compounds for photoinitiated controlled MCF-7 cell death. Observed results unambiguously showed that AlkVZ could be a potential structural moiety for the design of a novel family of photodynamic therapy agents. The main advantage of the proposed substances is an oxygen-independent generation of active radicals, which play a pivotal role in the treatment of oxygen-deficient tumors.

Identifiants

DOI: 10.1021/acs.molpharmaceut.1c00780 PMID: 34889598
pubmed: 34889598
doi: 10.1021/acs.molpharmaceut.1c00780
doi:

Substances chimiques

Free Radicals 0
Photosensitizing Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

354-357

Auteurs

Darya E Votkina (DE)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.

Evgenii V Plotnikov (EV)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.

Pavel V Petunin (PV)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.
ORCID: 0000-0001-7101-5996

Elizaveta S Berdinskaya (ES)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.

Maria S Tretyakova (MS)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.

Gérard Audran (G)

Aix Marseille University, CNRS, ICR, case 551, Avenue Escadrille Normandie-Niemen, 13397 Cedex 20 Marseille, France.

Sylvain R A Marque (SRA)

Aix Marseille University, CNRS, ICR, case 551, Avenue Escadrille Normandie-Niemen, 13397 Cedex 20 Marseille, France.
ORCID: 0000-0002-3050-8468

Pavel S Postnikov (PS)

Research School of Chemistry & Applied Biomedical Sciences, Tomsk Polytechnic University, 30 Lenin Avenue, Tomsk 634050, Russia.
Department of Solid-State Engineering, University of Chemistry and Technology, 16628 Prague, Czech Republic.
ORCID: 0000-0001-9713-1290

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Alkylverdazyls as a Source of Alkyl Radicals...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Alkylverdazyls as a Source of Alkyl Radicals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Alkylverdazyls as a Source of Alkyl Radicals...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cellules MCF-7 › Alkylverdazyls as a Source of Alkyl Radicals...
questionsmedicales.fr › Thérapeutique › Photothérapie › Photothérapie dynamique › Alkylverdazyls as a Source of Alkyl Radicals...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Radiosensibilisants › Photosensibilisants › Alkylverdazyls as a Source of Alkyl Radicals...