Multiple sclerosis and myelin basic protein: insights into protein disorder and disease.
Disease
Disorder
Multiple sclerosis
Myelin
Myelin basic protein
Journal
Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312
Informations de publication
Date de publication:
Jan 2022
Jan 2022
Historique:
received:
11
06
2021
accepted:
24
11
2021
pubmed:
11
12
2021
medline:
5
4
2022
entrez:
10
12
2021
Statut:
ppublish
Résumé
Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS). MS is characterized by CNS inflammation, demyelination, and axonal loss. One of the main theories on the pathogenesis of MS suggests that exposure to foreign antigens causes the activation of cross-reactive T cells in genetically susceptible individuals, with MBP being a possible autoantigen. While a direct role for MBP as a primary antigen in human MS is unclear, it is clear that MBP and its functions in myelin formation and long-term maintenance are linked to MS. This review looks at some key molecular characteristics of MBP and its relevance to MS, as well as the mechanisms of possible molecular mimicry between MBP and some viral antigens. We also discuss the use of serum anti-myelin antibodies as biomarkers for disease. MBP is a prime example of an apparently simple, but in fact biochemically and structurally complex molecule, which is closely linked to both normal nervous system development and neurodegenerative disease.
Identifiants
pubmed: 34889995
doi: 10.1007/s00726-021-03111-7
pii: 10.1007/s00726-021-03111-7
pmc: PMC8810476
doi:
Substances chimiques
Autoantigens
0
Myelin Basic Protein
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-109Informations de copyright
© 2021. The Author(s).
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