Serum levels of proinflammatory cytokines and selected bioelements in perimenopausal women with regard to body mass index.
bioelements
body mass index
menopause
perimenopausal women
proinflammatory cytokines
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
received:
24
08
2021
accepted:
24
11
2021
pubmed:
11
12
2021
medline:
19
2
2022
entrez:
10
12
2021
Statut:
ppublish
Résumé
During the menopause, decreased estrogen levels may be accompanied by increased levels of inflammatory mediators. Many studies also show significant relationships between the levels of bioelements and proinflammatory cytokines. The aim of this study was to assess the levels of proinflammatory cytokines, C-reactive protein (CRP), and selected bioelements in perimenopausal women with regard to BMI. The study of 217 perimenopausal women involved the completion of questionnaires concerning sociodemographic and medical data, anthropometric measurements, and blood collection. In all studied women, the levels of IL-1β significantly positively correlated with Ca, Mg, and Sr; IFNγ significantly negatively correlated with Sr, and IL-6 with Mg. In women with a normal BMI, the levels of IL-1β significantly positively correlated with Ca and Sr, and CRP positively correlated with Zn. In overweight women, the levels of IL-1β positively correlated with Ca, IL-6 with Na, and IFNγ negatively correlated with Sr. In obese women, the levels of CRP positively correlated with Zn, TNFα with Mg, IFNγ with Cu and P. The levels of IL-6 negatively correlated with Ca and Mg. BMI may be one of the factors that affect the relationship between serum bioelement levels and the levels of proinflammatory cytokines and CRP in women, especially during the menopausal period.
Identifiants
pubmed: 34890370
pii: 203754
doi: 10.18632/aging.203754
pmc: PMC8714146
doi:
Substances chimiques
Cytokines
0
Interleukin-1beta
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
C-Reactive Protein
9007-41-4
Magnesium
I38ZP9992A
Calcium
SY7Q814VUP
Strontium
YZS2RPE8LE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
25025-25037Références
Autoimmun Rev. 2021 Mar;20(3):102763
pubmed: 33482337
Eur J Nutr. 2016 Oct;55(7):2179-97
pubmed: 26883916
Environ Toxicol Pharmacol. 2016 Sep;46:337-343
pubmed: 27552445
RMD Open. 2017 Feb 15;3(1):e000344
pubmed: 28243467
Biotherapy. 1991;3(2):143-58
pubmed: 2054255
Indian J Clin Biochem. 2007 Sep;22(2):96-100
pubmed: 23105692
Endocr Rev. 2002 Feb;23(1):90-119
pubmed: 11844745
Diabetes Res Clin Pract. 2005 Jul;69(1):29-35
pubmed: 15955385
J Trace Elem Med Biol. 2018 Jul;48:8-15
pubmed: 29773198
Nutr J. 2017 Sep 19;16(1):60
pubmed: 28927411
Nat Rev Immunol. 2018 Sep;18(9):545-558
pubmed: 29921905
Arterioscler Thromb Vasc Biol. 1999 Aug;19(8):1986-91
pubmed: 10446082
Adv Neurobiol. 2017;18:85-111
pubmed: 28889264
Annu Rev Med. 2000;51:245-70
pubmed: 10774463
Nutr Rev. 2009 Oct;67(10):559-72
pubmed: 19785688
Eur J Endocrinol. 2003 Aug;149(2):129-35
pubmed: 12887290
Menopause. 2010 Jan-Feb;17(1):25-54; quiz 55-6
pubmed: 20061894
Obes Rev. 2015 Dec;16(12):1081-93
pubmed: 26395622
Exp Mol Med. 2017 Nov 3;49(11):e388
pubmed: 29099095
Int J Obes (Lond). 2007 Sep;31(9):1412-9
pubmed: 17438557
Mol Cell Endocrinol. 2007 Jan 29;264(1-2):68-73
pubmed: 17118530
Circulation. 2000 Jul 4;102(1):42-7
pubmed: 10880413
Circulation. 2001 Apr 24;103(16):2055-9
pubmed: 11319194
Exp Gerontol. 2001 Mar;36(3):547-57
pubmed: 11250125
Rev Assoc Med Bras (1992). 2017 Feb;63(2):156-163
pubmed: 28355377
Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15161-6
pubmed: 10611355
Brain Behav Immun. 2018 May;70:61-75
pubmed: 29499302
Pharmacol Rep. 2006;58 Suppl:81-8
pubmed: 17332676
Inflammation. 2013 Feb;36(1):226-31
pubmed: 22961567
Age (Dordr). 2012 Apr;34(2):415-25
pubmed: 21487705
Lancet. 2005 Feb 12-18;365(9459):610-2
pubmed: 15708106
Diabetologia. 1997 Nov;40(11):1286-92
pubmed: 9389420
Biol Trace Elem Res. 2017 Mar;176(1):64
pubmed: 27718097
Prz Menopauzalny. 2014 Jun;13(3):162-8
pubmed: 26327849
Diabetes Care. 2008 Mar;31(3):576-82
pubmed: 18083792
FEBS Lett. 1997 Jun 2;409(1):79-85
pubmed: 9199508
Obes Res. 2003 Nov;11(11):1278-89
pubmed: 14627747
J Am Diet Assoc. 2008 Jan;108(1):145-8
pubmed: 18156002
Cytokine. 2005 Aug 21;31(4):251-7
pubmed: 16043358
J Biol Chem. 1992 Jul 5;267(19):13580-4
pubmed: 1618860
Am J Physiol Regul Integr Comp Physiol. 2014 Dec 15;307(12):R1458-70
pubmed: 25320344
Rev Assoc Med Bras (1992). 2013 Sep-Oct;59(5):429-34
pubmed: 24041908
J Clin Endocrinol Metab. 2009 Apr;94(4):1104-10
pubmed: 19126626
Am J Physiol Endocrinol Metab. 2001 Jun;280(6):E827-47
pubmed: 11350765
Int J Womens Health. 2017 Oct 25;9:781-788
pubmed: 29123427