Diabetes mellitus and tuberculosis, a systematic review and meta-analysis with sensitivity analysis for studies comparable for confounders.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
05
2021
accepted:
28
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
4
2
2022
Statut:
epublish
Résumé
Meta-analyses conducted so far on the association between diabetes mellitus (DM) and the tuberculosis (TB) development risk did not sufficiently take confounders into account in their estimates. The objective of this systematic review was to determine whether DM is associated with an increased risk of developing TB with a sensitivity analyses incorporating a wider range of confounders including age, gender, alcohol consumption, smoke exposure, and other comorbidities. Pubmed, Embase, Web of Science and Global Index Medicus were queried from inception until October 2020. Without any restriction to time of study, geographical location, and DM and TB diagnosis approaches, all observational studies that presented data for associations between DM and TB were included. Studies with no abstract or complete text, duplicates, and studies with wrong designs (review, case report, case series, comment on an article, and editorial) or populations were excluded. The odds ratios (OR) and their 95% confidence intervals were estimated by a random-effect model. The electronic and manual searches yielded 12,796 articles of which 47 were used in our study (23 case control, 14 cross-sectional and 10 cohort studies) involving 503,760 cases (DM or TB patients) and 3,596,845 controls. The size of the combined effect of TB risk in the presence of DM was OR = 2.3, 95% CI = [2.0-2.7], I2 = 94.2%. This statistically significant association was maintained in cohort (OR = 2.0, CI 95% = [1.5-2.4], I2 = 94.3%), case control (OR = 2.4, CI 95% = [2.0-2.9], I2 = 93.0%) and cross-sectional studies (OR = 2.5, CI 95% = [1.8-3.5], I2 = 95.2%). The association between DM and TB was also maintained in the sensitivity analysis including only studies with similar proportions of confounders between cases and controls. The substantial heterogeneity observed was mainly explained by the differences between geographic regions. DM is associated with an increased risk of developing latent and active TB. To further explore the role of DM in the development of TB, more investigations of the biological mechanisms by which DM increases the risk of TB are needed. PROSPERO, CRD42021216815.
Identifiants
pubmed: 34890419
doi: 10.1371/journal.pone.0261246
pii: PONE-D-21-16247
pmc: PMC8664214
doi:
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0261246Subventions
Organisme : European & Developing Countries Clinical Trials Partnership
ID : EDCTP_TMA2019PF-2705
Pays : Netherlands
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Syst Rev. 2018 Oct 15;7(1):161
pubmed: 30322409
Lancet Infect Dis. 2019 Mar;19(3):e65-e76
pubmed: 30554995
PLoS One. 2013 Nov 13;8(11):e78924
pubmed: 24236069
Lancet Diabetes Endocrinol. 2014 Sep;2(9):754-64
pubmed: 25194888
Chest. 2003 Jan;123(1):308-9; author reply 309
pubmed: 12527642
Am J Trop Med Hyg. 2006 Apr;74(4):604-11
pubmed: 16606993
PLoS One. 2020 Apr 24;15(4):e0231816
pubmed: 32330171
Trans R Soc Trop Med Hyg. 2015 Jun;109(6):400-7
pubmed: 25918218
Int J Tuberc Lung Dis. 2010 Dec;14(12):1513-7
pubmed: 21180207
J Diabetes Metab Disord. 2014 Dec 16;13(1):123
pubmed: 25551103
Stat Med. 2002 Jun 15;21(11):1539-58
pubmed: 12111919
Lancet Diabetes Endocrinol. 2014 Sep;2(9):730-9
pubmed: 25194886
Am J Epidemiol. 2008 Jun 15;167(12):1486-94
pubmed: 18400769
BMC Infect Dis. 2008 Jan 24;8:8
pubmed: 18218115
Lancet Infect Dis. 2009 Dec;9(12):737-46
pubmed: 19926034
Contemp Clin Trials. 2015 Nov;45(Pt A):139-45
pubmed: 26343745
Medicine (Baltimore). 2014 Oct;93(16):e96
pubmed: 25310745
PLoS One. 2011;6(8):e24215
pubmed: 21912626
Clujul Med. 2017;90(1):54-59
pubmed: 28246498
PLoS One. 2014 Mar 24;9(3):e92623
pubmed: 24663327
Clin Infect Dis. 2007 Aug 15;45(4):436-8
pubmed: 17638190
Arch Intern Med. 1992 Mar;152(3):547-50
pubmed: 1546917
Fam Pract. 2017 Sep 1;34(5):532-538
pubmed: 28369346
Int J Tuberc Lung Dis. 2019 Apr 1;23(4):507-513
pubmed: 31064631
Tuber Lung Dis. 1995 Dec;76(6):529-33
pubmed: 8593374
Eur J Clin Nutr. 1988 May;42(5):445-50
pubmed: 3396531
Chronic Illn. 2007 Sep;3(3):228-45
pubmed: 18083679
Am J Respir Crit Care Med. 2016 Nov 1;194(9):1152-1163
pubmed: 27181053
Int J Tuberc Lung Dis. 2014 Jan;18(1):79-83
pubmed: 24365557
Trop Med Int Health. 2015 May;20(5):650-657
pubmed: 25598275
BMC Infect Dis. 2019 Jul 16;19(1):627
pubmed: 31311495
J Am Dent Assoc. 1971 Mar;82(3):564-8
pubmed: 5276260
J Infect Dis. 2016 Apr 1;213(7):1163-72
pubmed: 26609005
Respirology. 2007 May;12(3):416-9
pubmed: 17539848
Transpl Infect Dis. 2006 Sep;8(3):148-56
pubmed: 16913973
Am J Public Health. 1994 Nov;84(11):1750-6
pubmed: 7977912
BMC Public Health. 2007 Sep 06;7:234
pubmed: 17822539
PLoS One. 2017 Nov 21;12(11):e0187967
pubmed: 29161276
Int J Tuberc Lung Dis. 2017 Jan 1;21(1):86-92
pubmed: 28157470
Arthritis Rheum. 2006 Feb 15;55(1):19-26
pubmed: 16463407
Nature. 2001 Dec 13;414(6865):813-20
pubmed: 11742414
Trop Med Int Health. 2017 Mar;22(3):261-268
pubmed: 27935650
Int J Tuberc Lung Dis. 2011 Nov;15(11):1436-44, i
pubmed: 21902876
Tubercle. 1990 Jun;71(2):135-8
pubmed: 2219464
BMC Public Health. 2008 Aug 14;8:289
pubmed: 18702821
Eur J Immunol. 2014 Mar;44(3):617-26
pubmed: 24448841
Lancet. 2006 Nov 11;368(9548):1689-95
pubmed: 17098088
Clin Infect Dis. 2017 Mar 15;64(6):719-727
pubmed: 27986673
Int J Tuberc Lung Dis. 2016 Jan;20(1):71-8
pubmed: 26688531
Iran J Public Health. 2016 Apr;45(4):441-50
pubmed: 27252913
Chronic Illn. 2012 Jun;8(2):121-34
pubmed: 22387690
Diabetes Care. 2011 Dec;34(12):2530-5
pubmed: 21972407
PLoS Med. 2008 Jul 15;5(7):e152
pubmed: 18630984
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
Trop Med Int Health. 2018 Oct;23(10):1058-1070
pubmed: 30062731
Am J Public Health. 1997 Apr;87(4):574-9
pubmed: 9146434
Clin Infect Dis. 2006 Sep 15;43(6):717-22
pubmed: 16912945
Rev Saude Publica. 2016 Dec 22;50:82
pubmed: 28099656
Clin Infect Dis. 2012 Mar;54(6):818-25
pubmed: 22238171
Respirology. 2015 Feb;20(2):340-7
pubmed: 25428131
PLoS One. 2012;7(8):e42592
pubmed: 22916137
Infect Dis Clin North Am. 1995 Mar;9(1):1-9
pubmed: 7769211
Trop Med Int Health. 2010 Jun;15(6):659-63
pubmed: 20406430
PLoS One. 2014 Nov 04;9(11):e110104
pubmed: 25369472
BMC Med. 2015 Jun 05;13:135
pubmed: 26048371
Scand J Infect Dis. 2014 May;46(5):384-91
pubmed: 24621055
Sci Rep. 2017 Apr 24;7(1):1090
pubmed: 28439071
Western Pac Surveill Response J. 2020 Mar 31;11(1):22-28
pubmed: 32963888
Diabetes Res Clin Pract. 2010 Jan;87(1):4-14
pubmed: 19896746
PLoS One. 2013 Dec 18;8(12):e82660
pubmed: 24367535
BMC Public Health. 2013 Oct 21;13:991
pubmed: 24144113
Global Health. 2009 Sep 14;5:9
pubmed: 19751503
Diabetes Res Clin Pract. 2018 May;139:366-379
pubmed: 29574108
J Natl Med Assoc. 1995 Mar;87(3):187-92
pubmed: 7731067
Am J Respir Crit Care Med. 2009 Sep 1;180(5):475-80
pubmed: 19542475
PLoS One. 2014 Dec 05;9(12):e114442
pubmed: 25478954
Eur J Clin Microbiol Infect Dis. 2014 Sep;33(9):1573-7
pubmed: 24781006
PLoS Med. 2016 Aug 09;13(8):e1002072
pubmed: 27505150
Int J Tuberc Lung Dis. 2006 Jun;10(6):696-700
pubmed: 16776459
Lancet Infect Dis. 2007 Jul;7(7):444
pubmed: 17597568
BMC Med. 2011 Jul 01;9:81
pubmed: 21722362
BMJ Open. 2019 Oct 28;9(10):e029948
pubmed: 31662365
Eur Respir J. 2019 Sep 12;54(3):
pubmed: 31221810