The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study.
American Indians
Arsenic
Arsenic metabolism
Arsenic methylation
Arsenic species
Cancer
Cardiovascular disease
Mortality
Strong Heart Study
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
15 01 2022
15 01 2022
Historique:
received:
09
07
2021
revised:
03
12
2021
accepted:
03
12
2021
pubmed:
11
12
2021
medline:
17
3
2022
entrez:
10
12
2021
Statut:
ppublish
Résumé
The effect of low-moderate levels of arsenic exposure and of arsenic metabolism on mortality remains uncertain. We used data from a prospective cohort study in 3600 men and women aged 45 to 75 years living in Arizona, Oklahoma, and North and South Dakota. The biomarker of inorganic arsenic exposure was the sum of urine inorganic (iAs), monomethylated (MMA) and dimethylated (DMA) arsenic compounds (ƩAs) at baseline. The proportions of urine iAs, MMA and DMA over the ƩiAs, expressed as iAs%, MMA%, and DMA%, respectively, were used as biomarkers of arsenic metabolism. Arsenic exposure and arsenic metabolism were associated with all-cause, cardiovascular, and cancer mortality. For each interquartile range (IQR) increase in ƩAs (12.5 μg/L, overall range 0.7-194.1 μg/L), the adjusted hazard ratios (aHRs) were 1.28 (95% CI 1.16-1.41) for all-cause mortality, 1.28 (1.08-1.52) for cardiovascular mortality and 1.15 (0.92-1.44) for cancer mortality. The aHR for mortality for each IQR increase in MMA%, when iAs% is decreasing, was 1.52 (95% CI 1.16-1.99) for cardiovascular disease, 0.73 (0.55-0.98) for cancer, and 1.03 (0.90-1.19) for all-cause mortality. These findings at low-moderate levels of arsenic exposure highlight the need to implement public health measures to protect populations from involuntary arsenic exposure and for research to advance the biological and clinical understanding of arsenic-related health effects in general populations.
Identifiants
pubmed: 34890900
pii: S0160-4120(21)00654-1
doi: 10.1016/j.envint.2021.107029
pmc: PMC9123362
mid: NIHMS1800435
pii:
doi:
Substances chimiques
Arsenicals
0
Arsenic
N712M78A8G
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107029Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL041642
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL041654
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL090863
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL041652
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL065521
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES021367
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES009089
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
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