Genetic Reduction of Mitochondria Complex I Subunits is Protective against Cisplatin-Induced Neurotoxicity in
CIPN
Drosophila
cisplatin
complex I
mitochondria
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
02 02 2022
02 02 2022
Historique:
received:
03
06
2020
revised:
04
11
2021
accepted:
04
12
2021
pubmed:
12
12
2021
medline:
16
2
2022
entrez:
11
12
2021
Statut:
ppublish
Résumé
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent side effect of widely used platinum-based anticancer agents. There are few predictable risk factors with which to identify susceptible patients. Effective preventive measures or treatments are not available. Here, we have used a model of CIPN in
Identifiants
pubmed: 34893548
pii: JNEUROSCI.1479-20.2021
doi: 10.1523/JNEUROSCI.1479-20.2021
pmc: PMC8808726
doi:
Substances chimiques
Antineoplastic Agents
0
Drosophila Proteins
0
ND-13A protein, Drosophila
0
Electron Transport Complex I
EC 7.1.1.2
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
922-937Informations de copyright
Copyright © 2022 the authors.
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