The role of calcium oscillations in the phenotype selection in endothelial cells.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
received:
31
08
2021
accepted:
07
11
2021
entrez:
11
12
2021
pubmed:
12
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Angiogenesis is an important process in the formation and maintenance of tissues which is driven by a complex system of intracellular and intercellular signaling mechanisms. Endothelial cells taking part in early angiogenesis must select their phenotype as either a tip cells (leading, migratory) or a stalk cells (following). Recent experiments have demonstrated that rapid calcium oscillations within active cells characterize this phenotype selection process and that these oscillations play a necessary role in governing phenotype selection and eventual vessel architecture. In this work, we develop a mathematical model capable of describing these oscillations and their role in phenotype selection then use it to improve our understanding of the biological mechanisms at play. We developed a model based on two previously published and experimentally validated mathematical models of calcium and angiogenesis then use our resulting model to simulate various multi-cell scenarios. We are able to capture essential calcium oscillation dynamics and intercellular communication between neighboring cells. The results of our model show that although the late DLL4 (a transmembrane protein that activates Notch pathway) levels of a cell are connected with its initial IP3 (Inositol 1,4,5-trisphosphate) level, cell-to-cell communication determines its eventual phenotype.
Identifiants
pubmed: 34893636
doi: 10.1038/s41598-021-02720-2
pii: 10.1038/s41598-021-02720-2
pmc: PMC8664853
doi:
Substances chimiques
Biomarkers
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
23781Subventions
Organisme : CIHR
ID : 51771-10107
Pays : Canada
Informations de copyright
© 2021. The Author(s).
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