Epigenome association study for DNA methylation biomarkers in buccal and monocyte cells for female rheumatoid arthritis.
Adult
Aged
Arthritis, Rheumatoid
/ etiology
Autoimmunity
/ genetics
Biomarkers
Computational Biology
/ methods
DNA Methylation
Disease Susceptibility
Epigenesis, Genetic
Epigenomics
/ methods
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Regulatory Networks
Humans
Middle Aged
Monocytes
/ immunology
Mouth Mucosa
/ immunology
Sex Factors
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 12 2021
10 12 2021
Historique:
received:
02
09
2021
accepted:
17
11
2021
entrez:
11
12
2021
pubmed:
12
12
2021
medline:
27
1
2022
Statut:
epublish
Résumé
Genetics (i.e., mutations) has been assumed to be the major factor in rheumatoid arthritis (RA) etiology, but accounts for a minority of the variance in disease risk for RA. In contrast to genetics, the environment can have dramatic impacts on epigenetics that associate with disease etiology. The current study used buccal cells and purified blood monocytes from two different clinical cohorts involving Caucasian or African American female populations with or without arthritis. The differential DNA methylation regions (DMRs) between the control and RA populations were identified with an epigenome-wide association study. The DMRs (i.e., epimutations) identified in the buccal cells and monocytes were found to be distinct. The DMR associated genes were identified and many have previously been shown to be associated with arthritis. Observations demonstrate DNA methylation epimutation RA biomarkers are cell type specific and similar findings were observed with the two racial background populations. Rheumatoid arthritis susceptibility epigenetic diagnosis appears feasible and may improve the clinical management of RA and allowpreventative medicine considerations.
Identifiants
pubmed: 34893669
doi: 10.1038/s41598-021-03170-6
pii: 10.1038/s41598-021-03170-6
pmc: PMC8664902
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
23789Informations de copyright
© 2021. The Author(s).
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