Hierarchically Multivalent Peptide-Nanoparticle Architectures: A Systematic Approach to Engineer Surface Adhesion.
binding avidity
dendrimer-peptide conjugate
hierarchically multivalent architectures
multivalent binding
peptide engineering
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
04
11
2021
received:
04
08
2021
pubmed:
12
12
2021
medline:
22
3
2022
entrez:
11
12
2021
Statut:
ppublish
Résumé
The multivalent binding effect has been the subject of extensive studies to modulate adhesion behaviors of various biological and engineered systems. However, precise control over the strong avidity-based binding remains a significant challenge. Here, a set of engineering strategies are developed and tested to systematically enhance the multivalent binding of peptides in a stepwise manner. Poly(amidoamine) (PAMAM) dendrimers are employed to increase local peptide densities on a substrate, resulting in hierarchically multivalent architectures (HMAs) that display multivalent dendrimer-peptide conjugates (DPCs) with various configurations. To control binding behaviors, effects of the three major components of the HMAs are investigated: i) poly(ethylene glycol) (PEG) linkers as spacers between conjugated peptides; ii) multiple peptides on the DPCs; and iii) various surface arrangements of HMAs (i.e., a mixture of DPCs each containing different peptides vs DPCs cofunctionalized with multiple peptides). The optimized HMA configuration enables significantly enhanced target cell binding with high selectivity compared to the control surfaces directly conjugated with peptides. The engineering approaches presented herein can be applied individually or in combination, providing guidelines for the effective utilization of biomolecular multivalent interactions using DPC-based HMAs.
Identifiants
pubmed: 34894089
doi: 10.1002/advs.202103098
pmc: PMC8811846
doi:
Substances chimiques
Dendrimers
0
Peptides
0
Polyethylene Glycols
3WJQ0SDW1A
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2103098Subventions
Organisme : NIDCR NIH HHS
ID : P50 DE026787
Pays : United States
Organisme : Wisconsin Head & Neck Cancer SPORE Grant
ID : P50-DE026787
Organisme : National Science Foundation
ID : DMR-1808251
Organisme : National Research Foundation of Korea
ID : 2021R1A4A3024237
Informations de copyright
© 2021 The Authors. Advanced Science published by Wiley-VCH GmbH.
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