β-eye: A benchtop system for in vivo molecular screening of labeled compounds.
In vivo small animal imaging
Molecular imaging
Performance evaluation
Pharmacokinetic studies
Positron emission
Preclinical research
Journal
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
ISSN: 1872-9800
Titre abrégé: Appl Radiat Isot
Pays: England
ID NLM: 9306253
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
12
05
2021
revised:
26
10
2021
accepted:
16
11
2021
pubmed:
12
12
2021
medline:
12
12
2021
entrez:
11
12
2021
Statut:
ppublish
Résumé
Preclinical nuclear molecular imaging speeds up the mean time from synthesis to market, in drug development process. Commercial imaging systems have in general high cost, require high-cost service contracts, special facilities and trained staff. In the current work, we present β-eye, a benchtop system for in vivo molecular screening of labeled compounds with Positron Emission Tomography (PET) isotopes. The developed system is based on a dual-head geometry, offering simplicity and decreased cost. The goal of the design is to provide 2D, real-time radionuclide images of mice, allowing the recording of fast frames and thus perform fast kinetic studies, with spatial resolution of ∼2 mm. Performance evaluation demonstrates the ability of β-eye to provide quantitative results for injected activities lower than 1.5 MBq, which is adequate for pharmacodynamic studies in small mice.
Identifiants
pubmed: 34894480
pii: S0969-8043(21)00427-9
doi: 10.1016/j.apradiso.2021.110034
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110034Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.