Maternal inflammatory and omega-3 fatty acid pathways mediate the association between socioeconomic disadvantage and childhood cognition.

Child, Preschool Cognition Fatty Acids, Omega-3 Female Humans Mothers Pregnancy Socioeconomic Factors
Cognition Glyca Inflammation Maternal Mediation Metabolomics NMR Neurodevelopment Socioeconomic disadvantage

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
02 2022
Historique:
received: 27 09 2021
revised: 28 11 2021
accepted: 03 12 2021
pubmed: 14 12 2021
medline: 15 3 2022
entrez: 13 12 2021
Statut: ppublish

Résumé

Poor cognitive outcomes in early childhood predict poor educational outcomes and diminished health over the life course. We sought to investigate (i) whether maternal metabolites predict child cognition, and (ii) if maternal metabolomic profile mediates the relationship between environmental exposures and child cognition. Metabolites were measured using nuclear magnetic resonance-based metabolomics in pregnant women from a population-derived birth cohort. Child cognition was measured at age 2 years. In 662 mother-child pairs, elevated inflammatory markers (β = -2.62; 95% CI -4.10, -1.15; P = 0.0005) and lower omega-3 fatty acid-related metabolites (β = 0.49; 95% CI 0.09, 0.88; P = 0.02) in the mother were associated with lower child cognition and partially mediated the association between lower child cognition and multiple risk factors common to socioeconomic disadvantage. Modifying maternal prenatal metabolic pathways related to inflammation and omega-3 fatty acids may offset the adverse associations between prenatal risk factors related to socioeconomic disadvantage and low child cognition.

Identifiants

DOI: 10.1016/j.bbi.2021.12.002 PMID: 34896180
pubmed: 34896180
pii: S0889-1591(21)00633-4
doi: 10.1016/j.bbi.2021.12.002
pii:
doi:

Substances chimiques

Fatty Acids, Omega-3 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

211-218

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Wolfgang Marx (W)

Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 299 Ryrie Street, Geelong, VIC 3220, Australia.

Sarah Thomson (S)

Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia.

Martin O'Hely (M)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 299 Ryrie Street, Geelong, VIC 3220, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia.

Christos Symeonides (C)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; Minderoo Foundation, Perth, VIC 6000, Australia; Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia.

Fiona Collier (F)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 299 Ryrie Street, Geelong, VIC 3220, Australia.

Mimi L K Tang (MLK)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.

Amy Loughman (A)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 299 Ryrie Street, Geelong, VIC 3220, Australia.

David Burgner (D)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.

Richard Saffery (R)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.

Cindy Pham (C)

Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia.

Toby Mansell (T)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia.

Peter D Sly (PD)

Child Health Research Centre, The University of Queensland, 62 Graham St, South Brisbane, QLD 4101, Australia.

Peter Vuillermin (P)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, 299 Ryrie Street, Geelong, VIC 3220, Australia; Barwon Health, Bellerine St, Geelong, VIC 3220, Australia.

Sarath Ranganathan (S)

Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia.

Anne-Louise Ponsonby (AL)

Florey Institute for Neuroscience and Mental Health, 30 Royal Parade, Parkville, VIC 3052, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, 50 Flemington Rd, Parkville, VIC 3052, Australia. Electronic address: annelouise.ponsonby@florey.edu.au.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Enfant d'âge préscolaire › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Personnes › Parents › Mères › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Maternal inflammatory and omega-3 fatty acid...
questionsmedicales.fr › Caractéristiques de la population › Facteurs socioéconomiques › Maternal inflammatory and omega-3 fatty acid...