Mice lacking 5-lipoxygenase display motor deficits associated with cortical and hippocampal synapse abnormalities.

Animals Arachidonate 5-Lipoxygenase / deficiency Brain / metabolism CX3C Chemokine Receptor 1 / biosynthesis Cerebral Cortex / metabolism Hippocampus / metabolism Mice Microglia / metabolism Motor Disorders / etiology Neurons / metabolism Synapses / metabolism
5-lipoxygenase Behavior Cortical neurons and microglia Leukotrienes Memory Rotarod Synapse

Journal

Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478

Informations de publication

Date de publication:
02 2022
Historique:
received: 03 05 2021
revised: 02 12 2021
accepted: 04 12 2021
pubmed: 14 12 2021
medline: 15 3 2022
entrez: 13 12 2021
Statut: ppublish

Résumé

Neural-immune interactions are related to the synapse plasticity and other dynamic processes in the nervous system. The absence or dysfunction of cellular/molecular elements from the immune system lead to impairments in the central and peripheral nervous system with behavior consequences such as cognitive, sensory, and locomotor deficits as well as social disabilities and anxiety disturbances. Cellular interactions between immune cells such as macrophages, microglia, and neutrophils with glial or neuronal cells have been of increasing interest over the last years. However, little is known about the role of immune-derived soluble factors in the context of homeostasis of the nervous system. Leukotrienes (LTs) are lipid mediators derived from the oxidation of arachidonic acid by 5-lipoxygenase (5-LO), and are classically involved in inflammation, allergies, and asthma. Here, we demonstrated that adult mice lacking 5-LO (5-LO

Identifiants

DOI: 10.1016/j.bbi.2021.12.004 PMID: 34896181
pubmed: 34896181
pii: S0889-1591(21)00635-8
doi: 10.1016/j.bbi.2021.12.004
pii:
doi:

Substances chimiques

CX3C Chemokine Receptor 1 0
Cx3cr1 protein, mouse 0
Arachidonate 5-Lipoxygenase EC 1.13.11.34

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

183-193

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Maria Carolina Barbosa-Silva (MC)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Núcleo Multidisciplinar de Pesquisa em Biologia (Numpex-Bio), Campus de Duque de Caxias Geraldo Guerra Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ 25255-030, Brazil.

Raquel Maria P Campos (RM)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Ingrid Del Castilo (I)

Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Júlia V França (JV)

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Paula S Frost (PS)

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Carmen Penido (C)

Center for Technological Development in Health (CDTS)/nstitute of Drug Technology (Farmanguinhos), Oswaldo Cruz Foundation (Fiocruz), Rio de Janeiro, RJ, Brazil.

Julia R Clarke (JR)

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Claudio Canetti (C)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil.

Victor T Ribeiro-Resende (VT)

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-902, Brazil; Núcleo Multidisciplinar de Pesquisa em Biologia (Numpex-Bio), Campus de Duque de Caxias Geraldo Guerra Cidade, Universidade Federal do Rio de Janeiro, Duque de Caxias, RJ 25255-030, Brazil. Electronic address: vtulio@biof.ufrj.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Protéines à fer non hème › Lipoxygénases › Arachidonate lipoxygenases › Arachidonate 5-lipoxygenase › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteur-1 de la chimiokine CX3C › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Troubles mentaux › Troubles moteurs › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Cellules › Neurones › Mice lacking 5-lipoxygenase display motor...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Mice lacking 5-lipoxygenase display motor...