The purple mangosteen (Garcinia mangostana): Defining the anticancer potential of selected xanthones.
Anticancer
Chemoprevention
Garcinia mangostana
Garcinone C (PubChem CID: 44159808)
Garcinone E (10298511)
Gartanin (PubChem CID: 5281633)
Mangosteen
Prostate cancer
Xanthones
α-Mangostin (PubChem CID: 5281650)
β-Mangostin (PubChem CID: 5495925)
γ-Mangostin (PubChem CID: 5464078)
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
01
10
2021
revised:
03
12
2021
accepted:
07
12
2021
pubmed:
14
12
2021
medline:
8
4
2022
entrez:
13
12
2021
Statut:
ppublish
Résumé
The purple mangosteen (Garcinia mangostana) is a popular Southeast Asian fruit that has been used traditionally for its health promoting benefits for years. Unique to the mangosteen are a class of phytochemicals known as xanthones that have been reported to display significant anti-cancer and anti-tumor activities, specifically through the promotion of apoptosis, targeting of specific cancer-related proteins, or modulation of cell signaling pathways. α-Mangostin, the most abundant xanthone isolated from the mangosteen, has received substantial attention as it has proven to be a potent phytochemical, specifically as an anticancer agent, in numerous different cancer cell studies and cancer animal models. While the mechanisms for these anticancer effects have been reported in many studies, lesser xanthones, including gartanin, β-mangostin, γ-mangostin, garcinone C, and garcinone E, and mangosteen extracts from the pericarp, roots, rind, and stem show promise for their anticancer activity but their mechanisms of action are not as well developed and remain to be determined. Mangosteen products appear safe and have been well tolerated in human clinical trials where they show antioxidant activity, though their clinical anticancer activity has not yet been evaluated. This review summarizes the work that has been done to explore and explain the anticancer and antitumor activities of α-mangostin, lesser xanthones, and mangosteen extracts in vitro, in vivo, and in humans in various cancers.
Identifiants
pubmed: 34896543
pii: S1043-6618(21)00616-2
doi: 10.1016/j.phrs.2021.106032
pmc: PMC9597473
mid: NIHMS1796829
pii:
doi:
Substances chimiques
Anticarcinogenic Agents
0
Antineoplastic Agents, Phytogenic
0
Xanthones
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
106032Subventions
Organisme : NCI NIH HHS
ID : R37 CA227101
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA057699
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
Références
Eur J Pharmacol. 2019 Nov 15;863:172678
pubmed: 31542481
Evid Based Complement Alternat Med. 2016;2016:5352412
pubmed: 27478478
Drug Des Devel Ther. 2020 Dec 01;14:5315-5324
pubmed: 33293793
J Cell Mol Med. 2017 Jan;21(1):46-57
pubmed: 27491646
Asian Pac J Cancer Prev. 2020 Sep 01;21(9):2577-2583
pubmed: 32986355
J Agric Food Chem. 2012 Aug 29;60(34):8372-8
pubmed: 22779928
Molecules. 2017 Feb 12;22(2):
pubmed: 28208680
Fitoterapia. 2004 Jun;75(3-4):375-7
pubmed: 15158999
Odontology. 2013 Jul;101(2):227-32
pubmed: 22832848
Arch Oral Biol. 2011 May;56(5):483-90
pubmed: 21106189
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a001057
pubmed: 20182617
Nat Prod Res. 2021 Dec;35(23):5429-5433
pubmed: 32691623
Mol Cancer. 2014 Jun 03;13:138
pubmed: 24894151
Oncotarget. 2019 Sep 24;10(54):5576-5591
pubmed: 31608135
Antioxid Redox Signal. 2014 Aug 10;21(5):682-99
pubmed: 24295217
J Biomed Biotechnol. 2012;2012:672428
pubmed: 22577295
Mol Carcinog. 2020 Feb;59(2):193-201
pubmed: 31782573
Mol Nutr Food Res. 2011 May;55 Suppl 1:S67-74
pubmed: 21254395
Food Chem Toxicol. 2017 Nov;109(Pt 1):102-122
pubmed: 28842267
Asian Pac J Cancer Prev. 2004 Oct-Dec;5(4):433-8
pubmed: 15546251
J Agric Food Chem. 2011 May 25;59(10):5746-54
pubmed: 21446759
Cell Transplant. 2021 Jan-Dec;30:9636897211035080
pubmed: 34318699
J Ethnopharmacol. 2004 Jan;90(1):161-6
pubmed: 14698525
Food Chem Toxicol. 2012 Sep;50(9):3004-13
pubmed: 22705325
Oxid Med Cell Longev. 2016;2016:7981397
pubmed: 28053694
Environ Toxicol. 2017 Nov;32(11):2360-2370
pubmed: 28722351
Sci Rep. 2017 Sep 6;7(1):10718
pubmed: 28878295
Bioorg Med Chem. 2007 Aug 15;15(16):5620-8
pubmed: 17553685
Int J Mol Med. 2016 Apr;37(4):939-48
pubmed: 26951885
Cell Stress Chaperones. 2020 Jan;25(1):163-172
pubmed: 31898286
J Agric Food Chem. 2009 Oct 14;57(19):8788-92
pubmed: 19807152
Saudi J Biol Sci. 2018 Sep;25(6):1090-1095
pubmed: 30174507
Phytomedicine. 2020 Dec;79:153334
pubmed: 32920288
Carcinogenesis. 2012 Feb;33(2):413-9
pubmed: 22159229
Asian Pac J Cancer Prev. ;18(3):707-713
pubmed: 28441703
Acta Pharmacol Sin. 2014 Aug;35(8):1065-73
pubmed: 24976157
Oncotarget. 2017 Jul 18;8(29):47425-47439
pubmed: 28537893
Food Chem Toxicol. 2014 Apr;66:158-65
pubmed: 24480042
Front Pharmacol. 2013 Jun 26;4:80
pubmed: 23805102
Mol Nutr Food Res. 2013 Feb;57(2):203-11
pubmed: 23239542
Mol Nutr Food Res. 2009 May;53 Suppl 1:S54-61
pubmed: 19415666
J Agric Food Chem. 2011 Mar 9;59(5):2086-96
pubmed: 21314123
Int J Med Sci. 2018 Jan 1;15(1):23-30
pubmed: 29333084
PLoS One. 2013 Dec 18;8(12):e81572
pubmed: 24367485
Am J Cancer Res. 2021 May 15;11(5):1913-1935
pubmed: 34094661
Immune Netw. 2012 Dec;12(6):253-60
pubmed: 23396851
Nutrients. 2013 Aug 13;5(8):3163-83
pubmed: 23945675
Cancers (Basel). 2019 Oct 19;11(10):
pubmed: 31635099
Bioorg Med Chem. 2005 Nov 1;13(21):6064-9
pubmed: 16112579
Planta Med. 2013 May;79(8):646-53
pubmed: 23673465
Apoptosis. 2013 Dec;18(12):1548-60
pubmed: 23912717
Food Chem Toxicol. 2011 Sep;49(9):2385-91
pubmed: 21723363
Cell Physiol Biochem. 2017;44(4):1460-1470
pubmed: 29190630
Toxics. 2018 Oct 09;6(4):
pubmed: 30304811
Biochem Biophys Res Commun. 2014 Oct 10;453(1):75-80
pubmed: 25261723
RSC Adv. 2018 Dec 12;8(72):41377-41388
pubmed: 35559306
Int J Nutr. 2019;4(2):38-45
pubmed: 31363494
World J Gastroenterol. 2011 Apr 28;17(16):2086-95
pubmed: 21547127
Cell Biochem Biophys. 2010 Sep;58(1):31-44
pubmed: 20652762
J BUON. 2020 Sep-Oct;25(5):2293-2300
pubmed: 33277848
Biomed Res Int. 2014;2014:546353
pubmed: 24812621
Molecules. 2010 Dec 07;15(12):8953-66
pubmed: 21139533
PLoS One. 2016 May 06;11(5):e0155217
pubmed: 27152946
Int J Oncol. 2016 May;48(5):2155-65
pubmed: 26892433
BMC Med. 2011 Jun 03;9:69
pubmed: 21639868
J Nat Prod. 2008 Jul;71(7):1161-6
pubmed: 18558747
Adv Pharm Bull. 2020 Sep;10(4):648-655
pubmed: 33062605
J Cell Physiol. 2020 Nov;235(11):8446-8460
pubmed: 32324277
Expert Opin Ther Pat. 2018 May;28(5):415-427
pubmed: 29558225
Mol Cancer. 2020 Sep 24;19(1):145
pubmed: 32972405
J Pharm Pharmacol. 2013 Sep;65(9):1419-28
pubmed: 23927480
J Nat Prod. 2003 Aug;66(8):1124-7
pubmed: 12932141
Food Chem Toxicol. 2008 Oct;46(10):3227-39
pubmed: 18725264
Bioorg Med Chem. 2004 Nov 15;12(22):5799-806
pubmed: 15498656
Molecules. 2012 Mar 08;17(3):2939-54
pubmed: 22402764
PeerJ. 2019 Jan 31;7:e6324
pubmed: 30755827
J Food Sci. 2010 Jan-Feb;75(1):H13-23
pubmed: 20492173
Curr Colorectal Cancer Rep. 2017 Apr;13(2):101-110
pubmed: 28413363
Oncol Lett. 2013 Jun;5(6):1958-1964
pubmed: 23833675
Biomol Ther (Seoul). 2017 Nov 1;25(6):609-617
pubmed: 28822990
J Agric Food Chem. 2009 Feb 25;57(4):1291-8
pubmed: 19178296
Nutr Res. 2014 Apr;34(4):336-45
pubmed: 24774070
Chem Cent J. 2018 Oct 25;12(1):107
pubmed: 30361894
Phytother Res. 2015 Nov;29(11):1753-60
pubmed: 26310849
Molecules. 2012 Jul 03;17(7):8010-21
pubmed: 22759914
Anticancer Res. 2009 Jul;29(7):2485-95
pubmed: 19596918
Food Chem Toxicol. 2014 Apr;66:140-6
pubmed: 24472368
Biomed Pharmacother. 2017 Aug;92:672-680
pubmed: 28582759
J Nat Med. 2013 Apr;67(2):255-63
pubmed: 22622784
Food Sci Nutr. 2015 Jan;3(1):32-8
pubmed: 25649891
Appl Biochem Biotechnol. 2010 Oct;162(4):1080-94
pubmed: 20101528
J Med Food. 2009 Aug;12(4):755-63
pubmed: 19697997
J Nutr. 2012 Apr;142(4):675-80
pubmed: 22399525
Int J Oncol. 2016 Mar;48(3):1145-54
pubmed: 26781450
J Asian Nat Prod Res. 2008 May-Jun;10(5-6):475-9
pubmed: 18464091
Leuk Lymphoma. 2014 Mar;55(3):628-38
pubmed: 23734655
PLoS One. 2015 Jul 15;10(7):e0131587
pubmed: 26176540
Nutr J. 2009 Oct 20;8:48
pubmed: 19843321
Curr Drug Targets. 2012 Dec;13(14):1698-704
pubmed: 23140281
AMB Express. 2020 Jul 16;10(1):126
pubmed: 32676834
Oncol Rep. 2015 Jul;34(1):139-46
pubmed: 25955534
J Pharmacol Sci. 2004 May;95(1):33-40
pubmed: 15153648
Cancer Lett. 2014 May 28;347(1):129-38
pubmed: 24513179
Biochem Biophys Res Commun. 2014 Aug 8;450(4):1512-7
pubmed: 25019992
PLoS One. 2014 Apr 23;9(4):e96283
pubmed: 24759784
Curr Mol Med. 2011 Nov;11(8):666-77
pubmed: 21902651
Nutr Cancer. 2013;65 Suppl 1:68-77
pubmed: 23682785
Cell Death Dis. 2020 Jan 24;11(1):63
pubmed: 31980595
Mol Nutr Food Res. 2016 Jun;60(6):1458-69
pubmed: 27019217
Oncol Rep. 2018 Mar;39(3):1485-1493
pubmed: 29344638
BMC Complement Altern Med. 2012 Jul 20;12:104
pubmed: 22818000
Planta Med. 2002 Nov;68(11):975-9
pubmed: 12451486
Oncogene. 2004 Oct 28;23(50):8238-46
pubmed: 15378019
Methods Enzymol. 2006;407:597-612
pubmed: 16757355
Anticancer Res. 2012 Sep;32(9):3805-16
pubmed: 22993323
Food Sci Nutr. 2015 Jul;3(4):342-8
pubmed: 26286710