Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management.
5-nitro-gamma-tocopherol
Airway inflammation
Allergy
Alpha-tocopherol
Asthma
Cancer
Carcinogenesis,13'-carboxychromanol
Gamma-CEHC
Gamma-tocopherol
Inflammation
Nitrotyrosine
Vitamin E
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
31
08
2021
revised:
14
11
2021
accepted:
07
12
2021
pubmed:
14
12
2021
medline:
6
1
2022
entrez:
13
12
2021
Statut:
ppublish
Résumé
γ-Tocopherol (γT) is a major form of vitamin E in the US diet and the second most abundant vitamin E in the blood and tissues, while α-tocopherol (αT) is the predominant vitamin E in tissues. During the last >25 years, research has revealed that γT has unique antioxidant and anti-inflammatory activities relevant to disease prevention compared to αT. While both compounds are potent lipophilic antioxidants, γT but not αT can trap reactive nitrogen species by forming 5-nitro-γT, and appears to show superior protection of mitochondrial function. γT inhibits ionophore-stimulated leukotrienes by blocking 5-lipoxygenase (5-LOX) translocation in leukocytes, decreases cyclooxygenase-2 (COX-2)-catalyzed prostaglandins in macrophages and blocks the growth of cancer cells but not healthy cells. For these activities, γT is stronger than αT. Moreover, γT is more extensively metabolized than αT via cytochrome P-450 (CYP4F2)-initiated side-chain oxidation, which leads to formation of metabolites including 13'-carboxychromanol (13'-COOH) and carboxyethyl-hydroxychroman (γ-CEHC). 13'-COOH and γ-CEHC are shown to be the predominant metabolites found in feces and urine, respectively. Interestingly, γ-CEHC has natriuretic activity and 13'-COOH inhibits both COX-1/-2 and 5-LOX activity. Consistent with these mechanistic findings of γT and metabolites, studies show that supplementation of γT mitigates inflammation and disease symptoms in animal models with induced inflammation, asthma and cancer. In addition, supplementation of γT decreased inflammation markers in patients with kidney diseases and mild asthma. These observations support that γT may be useful against inflammation-associated diseases.
Identifiants
pubmed: 34896589
pii: S0891-5849(21)00863-7
doi: 10.1016/j.freeradbiomed.2021.12.012
pmc: PMC8826491
mid: NIHMS1763920
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Chromans
0
Vitamin E
1406-18-4
gamma-Tocopherol
8EF1Z1238F
alpha-Tocopherol
H4N855PNZ1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
347-359Subventions
Organisme : EPA
ID : 83578501
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025124
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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