Topical Review: Studies of Ocular Function and Disease Using Hyperspectral Imaging.
Journal
Optometry and vision science : official publication of the American Academy of Optometry
ISSN: 1538-9235
Titre abrégé: Optom Vis Sci
Pays: United States
ID NLM: 8904931
Informations de publication
Date de publication:
01 02 2022
01 02 2022
Historique:
pubmed:
14
12
2021
medline:
21
4
2022
entrez:
13
12
2021
Statut:
ppublish
Résumé
Advances in imaging technology over the last two decades have produced significant innovations in medical imaging. Hyperspectral imaging (HSI) is one of these innovations, enabling powerful new imaging tools for clinical use and greater understanding of tissue optical properties and mechanisms underlying eye disease.Hyperspectral imaging is an important and rapidly growing area in medical imaging, making possible the concurrent collection of spectroscopic and spatial information that is usually obtained from separate optical recordings. In this review, we describe several mainstream techniques used in HSI, along with noteworthy advances in optical technology that enabled modern HSI techniques. Presented also are recent applications of HSI for basic and applied eye research, which include a novel method for assessing dry eye syndrome, clinical slit-lamp examination of corneal injury, measurement of blood oxygen saturation in retinal disease, molecular changes in macular degeneration, and detection of early stages of Alzheimer disease. The review also highlights work resulting from integration of HSI with other imaging tools such as optical coherence tomography and autofluorescence microscopy and discusses the adaptation of HSI for clinical work where eye motion is present. Here, we present the background and main findings from each of these reports along with specific references for additional details.
Identifiants
pubmed: 34897230
doi: 10.1097/OPX.0000000000001853
pii: 00006324-202202000-00003
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-113Informations de copyright
Copyright © 2021 American Academy of Optometry.
Déclaration de conflit d'intérêts
Conflict of Interest Disclosure: SSM, JMB, and RV are named inventors on patent applications relating to the utility of hyperspectral imagery for diagnosis of neurodegeneration.
Références
Westheimer G. Directional Sensitivity of the Retina: 75 Years of Stiles-Crawford Effect. Proc Biol Sci 2008;275:2777–86.
Jacques SL. Optical Properties of Biological Tissues: A Review. Phys Med Biol 2013;58:R37–61.
Shapshay SM. Endoscopic Laser Surgery Handbook. New York, NY: Marcel Dekker; 1987.
Prahl S. Tabulated Molar Extinction Coefficient for Hemoglobin in Water; 1998. Available at: https://omlc.org/spectra/hemoglobin/summary.html . Accessed June 3, 2021.
Liu P, Zhu Z, Zeng C, et al. Specific Absorption Spectra of Hemoglobin at Different P o2 Levels: Potential Noninvasive Method to Detect P o2 in Tissues. J Biomed Opt 2012;17:125002.
More SS, Vince R. Hyperspectral Imaging Signatures Detect Amyloidopathy in Alzheimer's Mouse Retina Well Before Onset of Cognitive Decline. ACS Chem Neurosci 2015;6:306–15.
More SS, Beach JM, Vince R. Early Detection of Amyloidopathy in Alzheimer's Mice by Hyperspectral Endoscopy. Invest Ophthalmol Vis Sci 2016;57:3231–8.
More SS, Beach JM, McClelland C, et al. In Vivo Assessment of Retinal Biomarkers by Hyperspectral Imaging: Early Detection of Alzheimer's Disease. ACS Chem Neurosci 2019;10:4492–501.
Cohen Y, Epshtein S, Harris A, et al. Tear Film Imager for Dynamic Mapping of the Human Tear Film. Appl Opt 2019;58:7987–95.
MacKenzie LE, Choudhary TR, McNaught AI, et al. In Vivo Oximetry of Human Bulbar Conjunctival and Episcleral Microvasculature Using Snapshot Multispectral Imaging. Exp Eye Res 2016;149:48–58.
Harvey A, Fletcher-Holmes D, Gorman A, et al. Spectral Imaging in a Snapshot. Proc SPIE 2005;5694:110–9.
Johnson WR, Wilson DW, Fink W, et al. Snapshot Hyperspectral Imaging in Ophthalmology. J Biomed Opt 2007;12:014036.
Reshef ER, Miller JB, Vavvas DG. Hyperspectral Imaging of the Retina: A Review. Int Ophthalmol Clin 2020;60:85–96.
Kobrinski H, Cheung KW. Wavelength-tunable Optical Filters—Applications and Technologies. IEEE Commun Mag 1989;27:53–63.
Gil T, Cabib D, Adel M, et al. Spectral Bio-imaging of the Eye. U.S. patent US6276798B1. August 21, 2001.
Takahashi A, Camacho P, Lechleiter JD, et al. Measurement of Intracellular Calcium. Physiol Rev 1999;79:1089–125.
Medina JM, Pereira LM, Correia H, et al. Hyperspectral Optical Imaging of Human Iris in Vivo : Characteristics of Reflectance Spectra. J Biomed Opt 2011;16:076001.
Di Cecilia L, Rovati L. Design and Performance of a Hyperspectral Imaging System: Preliminary in Vivo Spectral Reflectance Measurements of the Human Iris. Rev Sci Instrum 2020;91:014104.
Ramachandran S, Taylor N, McNaught A, et al. Modeling of Light Propagation in Retinal Tissue. Proc SPIE 2004;5486:48–60.
Mordant DJ, Al-Abboud I, Muyo G, et al. Oxygen Saturation Measurements of the Retinal Vasculature in Treated Asymmetrical Primary Open-angle Glaucoma Using Hyperspectral Imaging. Eye 2014;28:1190–200.
Tayyari F, Khuu LA, Flanagan JG, et al. Retinal Blood Flow and Retinal Blood Oxygen Saturation in Mild to Moderate Diabetic Retinopathy. Invest Ophthalmol Vis Sci 2015;56:6796–800.
Hadoux X, Hui F, Lim JKH, et al. Non-invasive in Vivo Hyperspectral Imaging of the Retina for Potential Biomarker Use in Alzheimer's Disease. Nat Commun 2019;10:4227.
Shah TM, Gupta SM, Goozee K, et al. Hyperspectral Retinal Imaging Shows Amyloid-like Deposits in Preclinical Alzheimer's Disease. Alzheimers Dement 2020;16:e044128.
Noor SS, Michael K, Marshall S, et al. The Properties of the Cornea Based on Hyperspectral Imaging: Optical Biomedical Engineering Perspective. 2016 International Conference on Systems, Signals and Image Processing (IWSSIP). 2016:1–4. Available at: https://ieeexplore.ieee.org/document/7502710 . Accessed November 30, 2021.
Noor SSM, Michael K, Marshall S, et al. Hyperspectral Image Enhancement and Mixture Deep-learning Classification of Corneal Epithelium Injuries. Sensors (Basel) 2017;17:2644.
Khoobehi B, Beach JM, Kawano H. Hyperspectral Imaging for Measurement of Oxygen Saturation in the Optic Nerve Head. Invest Ophthalmol Vis Sci 2004;45:1464–72.
Beach J, Ning J, Khoobehi B. Oxygen Saturation in Optic Nerve Head Structures by Hyperspectral Image Analysis. Curr Eye Res 2007;32:161–70.
Li Q, Xue Y, Xiao G, et al. New Microscopic Pushbroom Hyperspectral Imaging System for Application in Diabetic Retinopathy Research. J Biomed Opt 2007;12:064011.
Li Q, Wang Y, Zhang J, et al. Quantitative Analysis of Protective Effect of Erythropoietin on Diabetic Retinal Cells Using Molecular Hyperspectral Imaging Technology. IEEE Trans Biomed Eng 2010;57:1699–706.
Vandenabeele M, Veys L, Lemmens S, et al. The App Nl-G-F Mouse Retina Is a Site for Preclinical Alzheimer's Disease Diagnosis and Research. Acta Neuropathol Commun 2021;9:6.
Beach JM, Schwenzer KJ, Srinivas S, et al. Oximetry of Retinal Vessels by Dual-wavelength Imaging: Calibration and Influence of Pigmentation. J Appl Physiol 1999;86:748–58.
Tiedeman JS, Kirk SE, Srinivas S, et al. Retinal Oxygen Consumption during Hyperglycemia in Patients with Diabetes without Retinopathy. Ophthalmology 1998;105:31–6.
Hardarson SH, Stefánsson E. Retinal Oxygen Saturation Is Altered in Diabetic Retinopathy. Br J Ophthalmol 2012;96:560–3.
Hammer M, Vilser W, Riemer T, et al. Diabetic Patients with Retinopathy Show Increased Retinal Venous Oxygen Saturation. Graefes Arch Clin Exp Ophthalmol 2009;247:1025–30.
Khoobehi B, Firn K, Thompson H, et al. Retinal Arterial and Venous Oxygen Saturation Is Altered in Diabetic Patients. Invest Ophthalmol Vis Sci 2013;54:7103–6.
Šínová I, Chrapek O, Mlčák P, et al. Automatic Retinal Oxymetry in Patients with Diabetic Retinopathy. Cesk Slov Oftalmol 2016;72:182–6.
Olafsdottir OB, Hardarson SH, Gottfredsdottir MS, et al. Retinal Oximetry in Primary Open-angle Glaucoma. Invest Ophthalmol Vis Sci 2011;52:6409–13.
Carichino L, Harris A, Guidoboni G, et al. A Theoretical Investigation of the Increase in Venous Oxygen Saturation Levels in Advanced Glaucoma Patients. Model Artif Intell Ophthalmol 2016;1:64–87.
Vandewalle E, Abegão Pinto L, Olafsdottir OB, et al. Oximetry in Glaucoma: Correlation of Metabolic Change with Structural and Functional Damage. Acta Ophthalmol 2014;92:105–10.
Van Keer K, Abegão Pinto L, Willekens K, et al. Correlation between Peripapillary Choroidal Thickness and Retinal Vessel Oxygen Saturation in Young Healthy Individuals and Glaucoma Patients. Invest Ophthalmol Vis Sci 2015;56:3758–62.
Descour MR, Volin CE, Dereniak EL, et al. Demonstration of a High-speed Nonscanning Imaging Spectrometer. Opt Lett 1997;22:1271–3.
Nourrit V, Denniss J, Muqit MM, et al. High-resolution Hyperspectral Imaging of the Retina with a Modified Fundus Camera. J Fr Ophtalmol 2010;33:686–92.
Fawzi AA, Lee N, Acton JH, et al. Recovery of Macular Pigment Spectrum in Vivo Using Hyperspectral Image Analysis. J Biomed Opt 2011;16:106008.
Barducci A, Guzzi D, Lastri C, et al. Theoretical Aspects of Fourier Transform Spectrometry and Common Path Triangular Interferometers. Opt Express 2010;18:11622–49.
Zamora G, Truitt PW, Nemeth SC, et al. Hyperspectral Imaging Analysis for Ophthalmic Applications. Proc SPIE 5314, Ophthalmic Technologies XIV. July 13, 2004. Available at: https://doi.org/10.1117/12.530796 .
doi: 10.1117/12.530796
Harper DJ, Konegger T, Augustin M, et al. Hyperspectral Optical Coherence Tomography for in Vivo Visualization of Melanin in the Retinal Pigment Epithelium. J Biophotonics 2019;12:e201900153.
Ben Ami T, Tong Y, Bhuiyan A, et al. Spatial and Spectral Characterization of Human Retinal Pigment Epithelium Fluorophore Families by ex Vivo Hyperspectral Autofluorescence Imaging. Transl Vis Sci Technol 2016;5:5.
Tong Y, Ach T, Curcio CA, et al. Hyperspectral Autofluorescence Characterization of Drusen and Sub-RPE Deposits in Age-related Macular Degeneration. Ann Eye Sci 2021;6:4.
Caspersson T, Schultz J. Ribonucleic Acids in Both Nucleus and Cytoplasm, and the Function of the Nucleolus. Proc Natl Acad Sci U S A 1940;26:507–15.
Caspersson T. Techniques for Cytochemical Studies of the Nucleus and Its Substructures. In: Nicolini CA, ed. Chromatin Structure and Function: Molecular and Cellular Biophysical Methods. Boston, MA: Springer US; 1979:251–64.
Gat N. Imaging Spectroscopy Using Tunable Filters: A Review. Proc SPIE 2000;4056:50–64.
Slawson RW, Ninkov Z, Horch EP. Hyperspectral Imaging: Wide-area Spectrophotometry Using a Liquid-crystal Tunable Filter. Publ Astron Soc Pac 1999;111:621–6.
Zuzak KJ, Schaeberle MD, Lewis EN, et al. Visible Reflectance Hyperspectral Imaging: Characterization of a Noninvasive, in Vivo System for Determining Tissue Perfusion. Anal Chem 2002;74:2021–8.
Lerner JM. Imaging Spectrometer Fundamentals for Researchers in the Biosciences—A Tutorial. Cytometry A 2006;69:712–34.
Dessy RE, Nunn WG, Titus CA, et al. Linear Photodiode Array Spectrometers as Detector Systems in Automated Liquid Chromatographs. J Chromatogr Sci 1976;14:195–200.
Jones DG. Photodiode Array Detectors in UV-VIS Spectroscopy: Part I. Anal Chem 1985;57:1057A–3.
Beach JM, Fager RS. A Flash Kinetic Spectrophotometer Employing Photodiode Array Sensors. IEEE Trans Biomed Eng 1984;BME-31:414–9.
Lim HT, Murukeshan VM. Pushbroom Hyperspectral Imaging System with Selectable Region of Interest for Medical Imaging. J Biomed Opt 2015;20:046010.
Hickam JB, Sieker HO, Frayser R. Studies of Retinal Circulation and A-V Oxygen Difference in Man. Trans Am Clin Climatol Assoc 1959;71:34–44.
Hickam JB, Frayser R, Ross JC. A Study of Retinal Venous Blood Oxygen Saturation in Human Subjects by Photographic Means. Circulation 1963;27:375–85.
Hammer M, Vilser W, Riemer T, et al. Retinal Vessel Oximetry-calibration, Compensation for Vessel Diameter and Fundus Pigmentation, and Reproducibility. J Biomed Opt 2008;13:054015.
Boote C, Sigal IA, Grytz R, et al. Scleral Structure and Biomechanics. Prog Retin Eye Res 2020;74:100773.
Johnson ME, Murphy PJ. Changes in the Tear Film and Ocular Surface from Dry Eye Syndrome. Prog Retin Eye Res 2004;23:449–74.
Beach JM, Uertz JL, Eckhardt LG. Hyperspectral Interferometry: Sizing Microscale Surface Features in the Pine Bark Beetle. Microsc Res Tech 2015;78:873–85.
Hecht E. Optics Global Edition. 5th ed. England, United Kingdom: Pearson Education; 2016.
Wipperman JL, Dorsch JN. Evaluation and Management of Corneal Abrasions. Am Fam Physician 2013;87:114–20.
Laing RA. Specular Microscopy of the Cornea. Curr Top Eye Res 1980;3:157–218.
Nahhas AF, Abdel-Malek ZA, Kohli I, et al. The Potential Role of Antioxidants in Mitigating Skin Hyperpigmentation Resulting from Ultraviolet and Visible Light-induced Oxidative Stress. Photodermatol Photoimmunol Photomed 2019;35:420–8.
Scheie HG, Yanoff M. Iris Nevus (Cogan-Reese) Syndrome. A Cause of Unilateral Glaucoma. Arch Ophthalmol 1975;93:963–70.
Fearnley IR, Rosenthal AR. Fuchs' Heterochromic Iridocyclitis Revisited. Acta Ophthalmol Scand 1995;73:166–70.
Sherrard ES, Frangoulis MA, Muir MG, et al. The Posterior Surface of the Cornea in the Irido-corneal Endothelial Syndrome: A Specular Microscopical Study. Trans Ophthalmol Soc UK 1985;104(Pt 7):766–74.
Siddiqui Y, Ten Hulzen RD, Cameron JD, et al. What Is the Risk of Developing Pigmentary Glaucoma from Pigment Dispersion Syndrome?Am J Ophthalmol 2003;135:794–9.
Rodarmel C, Shan J. Principal Component Analysis for Hyperspectral Image Classification. Surv Land Info Sci 2002;62:115–22.
Hardarson SH, Harris A, Karlsson RA, et al. Automatic Retinal Oximetry. Invest Ophthalmol Vis Sci 2006;47:5011–6.
Mordant DJ, Al-Abboud I, Muyo G, et al. Validation of Human Whole Blood Oximetry, Using a Hyperspectral Fundus Camera with a Model Eye. Invest Ophthalmol Vis Sci 2011;52:2851–9.
Stefánsson E, Olafsdottir OB, Einarsdottir AB, et al. Retinal Oximetry Discovers Novel Biomarkers in Retinal and Brain Diseases. Invest Ophthalmol Vis Sci 2017;58:BIO227–33.
Roy S, Ha J, Trudeau K, et al. Vascular Basement Membrane Thickening in Diabetic Retinopathy. Curr Eye Res 2010;35:1045–56.
Kohner EM, Patel V, Rassam SM. Role of Blood Flow and Impaired Autoregulation in the Pathogenesis of Diabetic Retinopathy. Diabetes 1995;44:603–7.
Kiyota N, Shiga Y, Suzuki S, et al. The Effect of Systemic Hyperoxia on Optic Nerve Head Blood Flow in Primary Open-angle Glaucoma Patients. Invest Ophthalmol Vis Sci 2017;58:3181–8.
Margrain TH, Atkinson D, Binns AM, et al. Functional Imaging of the Outer Retinal Complex Using High Fidelity Imaging Retinal Densitometry. Sci Rep 2020;10:4494.
Smith MH, Denninghoff KR, Lompado A, et al. Effect of Multiple Light Paths on Retinal Vessel Oximetry. Appl Opt 2000;39:1183–93.
van de Kraats J, van Norren D. Optical Density of the Aging Human Ocular Media in the Visible and the UV. J Opt Soc Am (A) 2007;24:1842–57.
Shu X, Beckmann L, Zhang H. Visible-light Optical Coherence Tomography: A Review. J Biomed Opt 2017;22:1–14.
Garg AK, Knight D, Lando L, et al. Advances in Retinal Oximetry. Transl Vis Sci Technol 2021;10:5.
Firn K, Khoobehi B. Novel Noninvasive Multispectral Snapshot Imaging System to Measure and Map the Distribution of Human Vessel and Tissue Hemoglobin Oxygen Saturation. Int J Ophthal Res 2015;1:48–58.