The gut microbiota profile in psoriasis: a Brazilian case-control study.
Akkermansia muciniphila
dysbiosis
gut microbiome
inflammatory bowel disease
psoriasis
psoriatic arthritis
skin disease
Journal
Letters in applied microbiology
ISSN: 1472-765X
Titre abrégé: Lett Appl Microbiol
Pays: England
ID NLM: 8510094
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
revised:
05
11
2021
received:
21
09
2021
accepted:
06
12
2021
pubmed:
14
12
2021
medline:
18
3
2022
entrez:
13
12
2021
Statut:
ppublish
Résumé
The pathogenesis of psoriasis, an immune-mediated chronic inflammatory skin disease, remains unclear. Studies have shown an association between psoriasis and intestinal inflammation; in this context, the influence of the gut microbiota on the immune response of psoriasis has become a focus of recent research. The present research evaluated the composition and diversity of the gut microbiota of 21 participants with psoriasis from a Brazilian referral dermatology service compared to 24 healthy controls. A stool sample was collected from each participant at the time of inclusion in the study, and the samples were analysed by sequencing the 16S rRNA gene. The recruitment of research participants involved matching between groups by sex, age, body mass index, comorbidities and smoking and the exclusion of several criteria that could potentially influence the gut microbiota and the interpretation of the data. There was an increase in the Dialister genus and Prevotella copri species in patients with psoriasis compared to the control group. A reduction in the Ruminococcus, Lachnospira and Blautia genera, as well as in the Akkermansia muciniphila species, was also verified in the psoriasis group compared to the control group. Furthermore, patients with psoriasis exhibited less gut microbiota diversity than controls.
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
498-504Subventions
Organisme : Sociedade Brasileira de Reumatologia
Informations de copyright
© 2021 The Society for Applied Microbiology.
Références
Balato, A., Cacciapuoti, S., Di Caprio, R., Marasca, C., Masarà, A., Raimondo, A. and Fabbrocini, G. (2019) Human microbiome: composition and role in inflammatory skin diseases. Arch Immunol Ther Exp (Warsz) 67, 1-18. https://doi.org/10.1007/s00005-018-0528-4
Callahan, B.J., McMurdie, P.J., Rosen, M.J., Han, A.W., Johnson, A.J. and Holmes, S.P. (2016) DADA2: high-resolution sample inference from Illumina amplicon data. Nat Methods 13, 581-583. https://doi.org/10.1038/nmeth.3869
Chen, Y.J., Ho, H.J., Tseng, C.H., Lai, Z.L., Shieh, J.J. and Wu, C.Y. (2018) Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients. Exp Dermatol 27, 1336-1343. https://doi.org/10.1111/exd.13786
Choo, J.M., Leong, L.E. and Rogers, G.B. (2015) Sample storage conditions significantly influence faecal microbiome profiles. Sci Rep 5, 16350. https://doi.org/10.1038/srep16350
Codoñer, F.M., Ramírez-Bosca, A., Climent, E., Carrión-Gutierrez, M., Guerrero, M., Pérez-Orquín, J.M., Horga de la Parte, J., Genovés, S. et al. (2018) Gut microbial composition in patients with psoriasis. Sci Rep 8, 3812. https://doi.org/10.1038/s41598-018-22125-y
Collado, M.C., Derrien, M., Isolauri, E., de Vos, W.M. and Salminen, S. (2007) Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly. Appl Environ Microbiol 73, 7767-7770. https://doi.org/10.1128/AEM.01477-07
Degnan, P.H. and Ochman, H. (2012) Illumina-based analysis of microbial community diversity. ISME J 6, 183-194. https://doi.org/10.1038/ismej.2011.74
Flint, H.J., Scott, K.P., Louis, P. and Duncan, S.H. (2012) The role of the gut microbiota in nutrition and health. Nat Rev Gastroenterol Hepatol 9, 577-589. https://doi.org/10.1038/nrgastro.2012.156
Fujimura, K.E., Slusher, N.A., Cabana, M.D. and Lynch, S.V. (2010) Role of the gut microbiota in defining human health. Expert Rev Anti Infect Ther 8, 435-454. https://doi.org/10.1586/eri.10.14
Goodrich, J.K., Di Rienzi, S.C., Poole, A.C., Koren, O., Walters, W.A., Caporaso, J.G., Knight, R. and Ley, R.E. (2014) Conducting a microbiome study. Cell 158, 250-262. https://doi.org/10.1016/j.cell.2014.06.037
Greb, J.E., Goldminz, A.M., Elder, J.T., Lebwohl, M.G., Gladman, D.D., Wu, J.J., Mehta, N.N., Finlay, A.Y. et al. (2016) Psoriasis. Nat Rev Dis Primers 24, 16082. https://doi.org/10.1038/nrdp.2016.82
Hidalgo-Cantabrana, C., Gómez, J., Delgado, S., Requena-López, S., Queiro-Silva, R., Margolles, A., Coto, E., Sánchez, B. et al. (2019) Gut microbiota dysbiosis in a cohort of patients with psoriasis. Br J Dermatol 181, 1287-1295. https://doi.org/10.1111/bjd.17931
Huang, L., Gao, R., Yu, N., Zhu, Y., Ding, Y. and Qin, H. (2019) Dysbiosis of gut microbiota was closely associated with psoriasis. Sci China Life Sci 62, 807-815. https://doi.org/10.1007/s11427-018-9376-6
Knight, R., Vrbanac, A., Taylor, B.C., Aksenov, A., Callewaert, C., Debelius, J., Gonzalez, A., Kosciolek, T. et al. (2018) Best practices for analysing microbiomes. Nat Rev Microbiol 16, 410-422. https://doi.org/10.1038/s41579-018-0029-9
Lin, D., Peters, B.A., Friedlander, C., Freiman, H.J., Goedert, J.J., Sinha, R., Miller, G., Bernstein, M.A. et al. (2018) Association of dietary fibre intake and gut microbiota in adults. Br J Nutr 120, 1014-1022. https://doi.org/10.1017/S0007114518002465
Liu, X., Mao, B., Gu, J., Wu, J., Cui, S., Wang, G., Zhao, J., Zhang, H. et al. (2021) Blautia-a new functional genus with potential probiotic properties? Gut Microbes 13, 1-21. https://doi.org/10.1080/19490976.2021.1875796
Massalat, D., Moemen, D. and State, A.F. (2016) Gut bacterial microbiota in psoriasis: a case control study. Afr J Microbiol Res 10, 1337-1343. https://doi.org/10.5897/AJMR2016.8046
Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.W. et al. (2019) The gut microbiome in psoriasis and psoriatic arthritis. Best Pract Res Clin Rheumatol 33, 101494. https://doi.org/10.1016/j.berh.2020.101494
Nicholson, J.K., Holmes, E., Kinross, J., Burcelin, R., Gibson, G., Jia, W. and Pettersson, S. (2012) Host-gut microbiota metabolic interactions. Science 336, 1262-1267. https://doi.org/10.1126/science.1223813
Parks, D.H., Tyson, G.W., Hugenholtz, P. and Beiko, R.G. (2014) STAMP: statistical analysis of taxonomic and functional profiles. Bioinformatics 30, 3123-3124. https://doi.org/10.1093/bioinformatics/btu494
Salem, I., Ramser, A., Isham, N. and Ghannoum, M.A. (2018) The gut microbiome as a major regulator of the gut-skin axis. Front Microbiol 9, 1459. https://doi.org/10.3389/fmicb.2018.01459
Scarpa, R., Manguso, F., D'Arienzo, A., D'Armiento, F.P., Astarita, C., Mazzacca, G. and Ayala, F. (2000) Microscopic inflammatory changes in colon of patients with both active psoriasis and psoriatic arthritis without bowel symptoms. J Rheumatol 27, 1241-1246. PMID: 10813294
Scher, J.U., Ubeda, C., Artacho, A., Attur, M., Isaac, S., Reddy, S.M., Marmon, S., Neimann, A. et al. (2015) Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease. Arthritis Rheumatol 67, 128-139. https://doi.org/10.1002/art.38892
Shapiro, J., Cohen, N.A., Shalev, V., Uzan, A., Koren, O. and Maharshak, N. (2019) Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls. J Dermatol 46, 595-603. https://doi.org/10.1111/1346-8138.14933
Tan, L., Zhao, S., Zhu, W., Wu, L., Li, J., Shen, M., Lei, L., Chen, X. et al. (2018) The Akkermansia muciniphila is a gut microbiota signature in psoriasis. Exp Dermatol 27, 144-149. https://doi.org/10.1111/exd.13463
Tito, R.Y., Cypers, H., Joossens, M., Varkas, G., Van Praet, L., Glorieus, E., Van den Bosch, F., De Vos, M. et al. (2017) Brief Report: dialister as a microbial marker of disease activity in spondyloarthritis. Arthritis Rheumatol 69, 114-121. https://doi.org/10.1002/art.39802
Wickham, H. (2016) ggplot2 Elegant Graphics for Data Analysis. Springer International Publishing. https://www.springer.com/gp/book/9780387981413. Accessed August 03, 2021.
Yan, D., Issa, N., Afifi, L., Jeon, C., Chang, H.W. and Liao, W. (2017) The role of the skin and gut microbiome in psoriatic disease. Curr Dermatol Rep 6, 94-103. https://doi.org/10.1007/s13671-017-0178-5
Yegorov, S., Babenko, D., Kozhakhmetov, S., Akhmaltdinova, L., Kadyrova, I., Nurgozhina, A., Nurgaziyev, M., Good, S.V. et al. (2020) Psoriasis is associated with elevated gut IL-1α and intestinal microbiome alterations. Front Immunol 11, 571319. https://doi.org/10.3389/fimmu.2020.571319
Yilmaz, P., Parfrey, L.W., Yarza, P., Gerken, J., Pruesse, E., Quast, C., Schweer, T., Peplies, J. et al. (2014) The SILVA and "All-species Living Tree Project (LTP)" taxonomic frameworks. Nucleic Acids Res 42(Database issue), D643-D648. https://doi.org/10.1093/nar/gkt1209
Zeng, J., Luo, S., Huang, Y. and Lu, Q. (2017) Critical role of environmental factors in the pathogenesis of psoriasis. J Dermatol 44, 863-872. https://doi.org/10.1111/1346-8138.13806