Effect of fluconazole and terbinafine nanoparticles on the treatment of dermatophytosis induced by
Fluconazole
Guinea pig
Nano-drugs
Terbinafine
Trichophyton mentagrophytes
Journal
Iranian journal of microbiology
ISSN: 2008-3289
Titre abrégé: Iran J Microbiol
Pays: Iran
ID NLM: 101518404
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
14
12
2021
Statut:
ppublish
Résumé
Dermatophytosis induced by Guinea pigs (n=36) were injected (the posterior dorsal portion) with Assessment of the mean score of clinical lesions in groups treated with nano-drug forms of fluconazole and terbinafine on the first day of treatment showed a score of 3 (significant redness with large scaling) and for the conventional form of terbinafine and fluconazole had a score of 4 (ulcer and scar). The decrease in lesion score in nano-drug treated groups was observed between days 15 and 20 and continued until day 40. On day 40, all groups had zero scores except the positive control group. This study indicated that nano-drugs are more suitable for the treatment of dermatophytosis and could be considered as future alternatives for the treatment of dermatophytosis.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Dermatophytosis induced by
MATERIALS AND METHODS
METHODS
Guinea pigs (n=36) were injected (the posterior dorsal portion) with
RESULTS
RESULTS
Assessment of the mean score of clinical lesions in groups treated with nano-drug forms of fluconazole and terbinafine on the first day of treatment showed a score of 3 (significant redness with large scaling) and for the conventional form of terbinafine and fluconazole had a score of 4 (ulcer and scar). The decrease in lesion score in nano-drug treated groups was observed between days 15 and 20 and continued until day 40. On day 40, all groups had zero scores except the positive control group.
CONCLUSION
CONCLUSIONS
This study indicated that nano-drugs are more suitable for the treatment of dermatophytosis and could be considered as future alternatives for the treatment of dermatophytosis.
Identifiants
pubmed: 34900158
doi: 10.18502/ijm.v13i5.7424
pii: IJM-13-608
pmc: PMC8629829
doi:
Types de publication
Journal Article
Langues
eng
Pagination
608-616Informations de copyright
Copyright © 2021 The Authors. Published by Tehran University of Medical Sciences.
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