Wnt2 Contributes to the Development of Atherosclerosis.
EndMT
HAECs
TGF-β
Wnt
atherosclerosis
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2021
2021
Historique:
received:
02
08
2021
accepted:
21
10
2021
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
14
12
2021
Statut:
epublish
Résumé
Atherosclerosis, is a chronic inflammatory disease, characterized by the narrowing of the arteries resulting from the formation of intimal plaques in the wall of arteries. Yet the molecular mechanisms responsible for maintaining the development and progression of atherosclerotic lesions have not been fully defined. In this study, we show that TGF-β activates the endothelial-to-mesenchymal transition (EndMT) in cultured human aortic endothelial cells (HAECs) and this transition is dependent on the key executor of the Wnt signaling pathway
Identifiants
pubmed: 34901211
doi: 10.3389/fcvm.2021.751720
pmc: PMC8652052
doi:
Types de publication
Journal Article
Langues
eng
Pagination
751720Informations de copyright
Copyright © 2021 Zhang, Rojas, Singh, Musich, Gutierrez, Yao, Thewke and Jiang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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