Adult Living-Donor Kidney Transplantation, Donor Age, and Donor-Recipient Age.
donor age
donor-recipient age difference
graft biopsy
graft loss
living-donor kidney transplantation
mortality
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
20
07
2021
revised:
30
09
2021
accepted:
04
10
2021
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
14
12
2021
Statut:
epublish
Résumé
Owing to organ shortage, the number of kidney transplantation (KT) involving older adult living donors is increasing. We aimed to investigate the effects of living-donor age and donor-recipient age differences on KT outcomes. This single-center, retrospective cohort study involved 853 adult LDKTs performed between January 2008 and December 2018. Recipients were stratified into the following 5 groups based on donor age and donor-recipient age difference: donor age, 30 to 49 years and age difference, -10 to 15 years; donor age, 50 to 69 years and age difference, -10 to 15 years; donor age, 50 to 69 years and age difference, 15 to 40 years; donor age, 70 to 89 years and age difference, -10 to 15 years; and donor age, 70 to 89 years and age difference, 15 to 40 years (groups 1, 2, 3, 4, and 5, respectively). As a primary outcome, the risk of graft loss was investigated. The secondary outcomes were postoperative estimated glomerular filtration rates (eGFRs) and mortality rates of recipients. Group 4, representing KT between older adult donors and older adult recipients, had the highest graft loss risk and mortality. The eGFRs of the recipients from donors aged 70 to 89 years (groups 4 and 5) were significantly lower than those from donors in the other groups. Although the differences in the eGFR between groups 4 and 5 were not significant, the eGFR of group 4 was lower than that of group 5 at 6 months post-KT. LDKTs from older adult donors to older adult recipients resulted in the worst graft survival and mortality rates.
Identifiants
pubmed: 34901571
doi: 10.1016/j.ekir.2021.10.002
pii: S2468-0249(21)01461-3
pmc: PMC8640566
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3026-3034Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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