Renal Prognosis in Children With Tubulointerstitial Nephritis and Uveitis Syndrome.
Dobrin’s syndrome
chronic kidney failure
outcome
pediatric
tubulointerstitial nephritis and uveitis syndrome
Journal
Kidney international reports
ISSN: 2468-0249
Titre abrégé: Kidney Int Rep
Pays: United States
ID NLM: 101684752
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
15
06
2021
revised:
27
09
2021
accepted:
30
09
2021
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
14
12
2021
Statut:
epublish
Résumé
Tubulointerstitial nephritis (TIN) and uveitis (TINU) syndrome is a rare disease. The renal prognosis is generally thought to be better in children with TINU syndrome than in adults. However, data are scarce. We aimed to investigate the long-term renal prognosis in a French cohort of children with TINU syndrome. We performed a national retrospective study including 23 French pediatric nephrology centers enrolling patients with TINU syndrome diagnosed between January 2000 and December 2018. A total of 46 patients were included (52% female, median age 13.8 years). At diagnosis of TIN, the median estimated glomerular filtration rate (eGFR) was 30.6 ml/min per 1.73 m In our study, nearly half of the patients had renal sequelae at last follow-up. Given the possible progression to chronic kidney disease, long-term monitoring of children with TINU syndrome is mandatory. Approximately a quarter of the children had asymptomatic uveitis suggesting all children presenting with TIN should undergo systematic ophthalmologic screening even in the absence of ocular signs.
Identifiants
pubmed: 34901573
doi: 10.1016/j.ekir.2021.09.017
pii: S2468-0249(21)01458-3
pmc: PMC8640547
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3045-3053Informations de copyright
© 2021 International Society of Nephrology. Published by Elsevier Inc.
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