Inherited L1 Retrotransposon Insertions Associated With Risk for Schizophrenia and Bipolar Disorder.

L1Hs/REBELseq

Journal

Schizophrenia bulletin open
ISSN: 2632-7899
Titre abrégé: Schizophr Bull Open
Pays: United States
ID NLM: 101770329

Informations de publication

Date de publication:
Jan 2021
Historique:
entrez: 13 12 2021
pubmed: 14 12 2021
medline: 14 12 2021
Statut: epublish

Résumé

Studies of the genetic heritability of schizophrenia and bipolar disorder examining single nucleotide polymorphisms (SNPs) and copy number variations have failed to explain a large portion of the genetic liability, resulting in substantial missing heritability. Long interspersed element 1 (L1) retrotransposons are a type of inherited polymorphic variant that may be associated with risk for schizophrenia and bipolar disorder. We performed REBELseq, a genome wide assay for L1 sequences, on DNA from male and female persons with schizophrenia and controls (

Identifiants

DOI: 10.1093/schizbullopen/sgab031 PMID: 34901866 PMC: PMC8650070
pubmed: 34901866
doi: 10.1093/schizbullopen/sgab031
pii: sgab031
pmc: PMC8650070
doi:

Types de publication

Journal Article

Langues

eng

Pagination

sgab031

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.

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Auteurs

Benjamin C Reiner (BC)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0001-7796-587X

Glenn A Doyle (GA)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Andrew E Weller (AE)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Rachel N Levinson (RN)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Aditya M Rao (AM)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Emilie Davila Perea (E)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Esin Namoglu (E)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Alicia Pigeon (A)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Gabriella Arauco-Shapiro (G)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Cyndi Shannon Weickert (CS)

Schizophrenia Research Laboratory, Neuroscience Research Australia & School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Department of Neuroscience & Physiology, Upstate Medical University, Syracuse, NY, USA.

Gustavo Turecki (G)

McGill Group for Suicide Studies, Douglas Mental Health University Institute, McGill University, Montreal, Canada.

Richard C Crist (RC)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Wade H Berrettini (WH)

Molecular and Neural Basis of Psychiatric Disease Section, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Classifications MeSH