Autophagy in healthy aging and disease.
Journal
Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
entrez:
13
12
2021
pubmed:
14
12
2021
medline:
14
12
2021
Statut:
ppublish
Résumé
Autophagy is a fundamental cellular process that eliminates molecules and subcellular elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated degradation to promote homeostasis, differentiation, development and survival. While autophagy is intimately linked to health, the intricate relationship among autophagy, aging and disease remains unclear. This Review examines several emerging features of autophagy and postulates how they may be linked to aging as well as to the development and progression of disease. In addition, we discuss current preclinical evidence arguing for the use of autophagy modulators as suppressors of age-related pathologies such as neurodegenerative diseases. Finally, we highlight key questions and propose novel research avenues that will likely reveal new links between autophagy and the hallmarks of aging. Understanding the precise interplay between autophagy and the risk of age-related pathologies across organisms will eventually facilitate the development of clinical applications that promote long-term health.
Identifiants
pubmed: 34901876
doi: 10.1038/s43587-021-00098-4
pmc: PMC8659158
mid: NIHMS1758486
doi:
Types de publication
Review
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
634-650Subventions
Organisme : NIA NIH HHS
ID : RF1 AG057296
Pays : United States
Organisme : NIA NIH HHS
ID : R37 AG026647
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG049665
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038664
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG054407
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM117466
Pays : United States
Organisme : Medical Research Council
ID : UKDRI-2002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02492X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P005535/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/T013273/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103830/Z/14/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C7893/A28990
Pays : United Kingdom
Déclaration de conflit d'intérêts
Competing interests E.F.F. has a CRADA arrangement with ChromaDex and is a consultant to Aladdin Healthcare Technologies, the Vancouver Dementia Prevention Centre and Intellectual Labs. A.K.S. is a consultant to Oxford Healthspan. D.C.R. is a consultant for Aladdin Healthcare Technologies, Drishti Discoveries and Nido Biosciences. G.K. is a scientific co-founder of everImmune, Samsara Therapeutics and Therafast Bio. All other authors declare no competing interests.
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