Association of changes in the infarct and remote zone myocardial tissue with cardiac remodeling after myocardial infarction: a T1 and T2 mapping study.
Extracellular volume
Left ventricular remodeling
Myocardial infarction
T1 mapping
T2 mapping
Journal
The international journal of cardiovascular imaging
ISSN: 1875-8312
Titre abrégé: Int J Cardiovasc Imaging
Pays: United States
ID NLM: 100969716
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
14
10
2021
accepted:
06
12
2021
pubmed:
14
12
2021
medline:
4
3
2022
entrez:
13
12
2021
Statut:
ppublish
Résumé
Tissue structure in the infarct and remote zone myocardium post-acute myocardial infarction (MI) may offer prognostic information concerning left ventricular remodeling. We aimed to identify or establish a relationship between adverse remodeling (AR) and changes (Δ) in T1, T2 mapping and extracellular volume (ECV) in post MI periods. Fifty-four MI patients underwent 3 Tesla CMR performed 2 weeks (acute phase) and 6 months post-MI. We measured T1 mapping with MOLLI sequences and T2 mapping with TrueFISP sequences. Hematocrit was quantified in scanning time. ECV was performed post-gadolinium enhancement. AR was defined as an increase of ≥ 10% in left ventricular end-diastolic volume in 6 months. In the acute phase post-MI, high T2 relaxation times of the infarct and remote zone myocardium were associated with AR (OR 1.15, p = 0.023 and OR 1.54, p = 0.002, respectively). There was a decrease in T2 relaxation times of the remote zone myocardium at 6 months in patients with AR (42.0 ± 4.0 vs. 39.0 ± 3.5 ms, p < 0.001), while insignificant difference was found in patients without AR. Increased ΔECV (%) and decreased remote ΔT2 values were associated with AR (OR 1.04, p = 0.043 and OR 0.77, p = 0.007, respectively). The diagnostic performance analysis in predicting AR showed that acute-phase remote T2 was similar to that of remote ΔT2 (p = 0.875) but was superior to that of ΔECV (%) (ΔAUC: 0.19 ± 0.09, p = 0.038). In both acute phase and change of 6 months post-MI, the T2 relaxation times in remote myocardium are independently associated with AR, and this suggests higher inflammation in the remote myocardium in the AR group than the other group, even though no significant pathophysiological difference was observed in the healing of the infarct zone between both groups.
Identifiants
pubmed: 34902103
doi: 10.1007/s10554-021-02490-y
pii: 10.1007/s10554-021-02490-y
doi:
Substances chimiques
Contrast Media
0
Gadolinium
AU0V1LM3JT
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
363-373Subventions
Organisme : Ministry of Health of the Republic of Turkey (Department Of Research, Development And Health Technology Evaluation)
ID : 2015/SAGEM-2/001
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
Références
Schulz-Menger J, Bluemke DA, Bremerich J, Flamm SD, Fogel MA, Friedrich MG et al (2013) Standardized image interpretation and post processing in cardiovascular magnetic resonance: society for cardiovascular magnetic resonance (SCMR) board of trustees task force on standardized post processing. J Cardiovasc Magn Reson 15:35. https://doi.org/10.1186/1532-429X-15-35
doi: 10.1186/1532-429X-15-35
pubmed: 23634753
pmcid: 3695769
Rodriguez-Palomares JF, Gavara J, Ferreira-Gonzalez I, Valente F, Rios C, Rodriguez-Garcia J et al (2019) Prognostic value of initial left ventricular remodeling in patients with reperfused STEMI. JACC Cardiovasc Imaging 12(12):2445–2456. https://doi.org/10.1016/j.jcmg.2019.02.025
doi: 10.1016/j.jcmg.2019.02.025
pubmed: 31202752
Ugander M, Bagi PS, Oki AJ, Chen B, Hsu LY, Aletras AH et al (2012) Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction. JACC Cardiovasc Imaging 5(6):596–603. https://doi.org/10.1016/j.jcmg.2012.01.016
doi: 10.1016/j.jcmg.2012.01.016
pubmed: 22698528
pmcid: 3769169
Perea RJ, Ortiz-Perez JT, Sole M, Cibeira MT, de Caralt TM, Prat-Gonzalez S et al (2015) T1 mapping: characterisation of myocardial interstitial space. Insights Imaging 6(2):189–202. https://doi.org/10.1007/s13244-014-0366-9
doi: 10.1007/s13244-014-0366-9
pubmed: 25424598
Abdel-Aty H, Simonetti O, Friedrich MG (2007) T2-weighted cardiovascular magnetic resonance imaging. J Magn Reson Imaging 26(3):452–459. https://doi.org/10.1002/jmri.21028
doi: 10.1002/jmri.21028
pubmed: 17729358
Biesbroek PS, Amier RP, Teunissen PFA, Hofman MBM, Robbers L, van de Ven PM et al (2017) Changes in remote myocardial tissue after acute myocardial infarction and its relation to cardiac remodeling: a CMR T1 mapping study. PLoS ONE 12(6):e0180115. https://doi.org/10.1371/journal.pone.0180115
doi: 10.1371/journal.pone.0180115
pubmed: 28644903
pmcid: 5482488
Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD et al (2012) Third universal definition of myocardial infarction. J Am Coll Cardiol 60(16):1581–1598. https://doi.org/10.1016/j.jacc.2012.08.001
doi: 10.1016/j.jacc.2012.08.001
pubmed: 22958960
Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al (2018) 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the task force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J 39(2):119–177. https://doi.org/10.1093/eurheartj/ehx393
doi: 10.1093/eurheartj/ehx393
pubmed: 28886621
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18(6):499–502
doi: 10.1093/clinchem/18.6.499
Eng J, McClelland RL, Gomes AS, Hundley WG, Cheng S, Wu CO et al (2016) Adverse left ventricular remodeling and age assessed with cardiac MR imaging: the multi-ethnic study of atherosclerosis. Radiology 278(3):714–722
doi: 10.1148/radiol.2015150982
Reindl M, Reinstadler SJ, Tiller C, Feistritzer H-J, Kofler M, Brix A et al (2019) Prognosis-based definition of left ventricular remodeling after ST-elevation myocardial infarction. Eur Radiol 29(5):2330–2339
doi: 10.1007/s00330-018-5875-3
Messroghli DR, Walters K, Plein S, Sparrow P, Friedrich MG, Ridgway JP et al (2007) Myocardial T1 mapping: application to patients with acute and chronic myocardial infarction. Magn Reson Med 58(1):34–40. https://doi.org/10.1002/mrm.21272
doi: 10.1002/mrm.21272
pubmed: 17659622
Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP (2004) Modified Look-Locker inversion recovery (MOLLI) for high-resolution T1 mapping of the heart. Magn Reson Med 52(1):141–146. https://doi.org/10.1002/mrm.20110
doi: 10.1002/mrm.20110
pubmed: 15236377
Carrick D, Haig C, Rauhalammi S, Ahmed N, Mordi I, McEntegart M et al (2016) Prognostic significance of infarct core pathology revealed by quantitative non-contrast in comparison with contrast cardiac magnetic resonance imaging in reperfused ST-elevation myocardial infarction survivors. Eur Heart J 37(13):1044–1059. https://doi.org/10.1093/eurheartj/ehv372
doi: 10.1093/eurheartj/ehv372
pubmed: 26261290
Giri S, Chung YC, Merchant A, Mihai G, Rajagopalan S, Raman SV et al (2009) T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson 11:56. https://doi.org/10.1186/1532-429X-11-56
doi: 10.1186/1532-429X-11-56
pubmed: 20042111
pmcid: 2809052
Verhaert D, Thavendiranathan P, Giri S, Mihai G, Rajagopalan S, Simonetti OP et al (2011) Direct T2 quantification of myocardial edema in acute ischemic injury. JACC Cardiovasc Imaging 4(3):269–278. https://doi.org/10.1016/j.jcmg.2010.09.023
doi: 10.1016/j.jcmg.2010.09.023
pubmed: 21414575
pmcid: 4282779
Bursac Z, Gauss CH, Williams DK, Hosmer DW (2008) Purposeful selection of variables in logistic regression. Source Code Biol Med 3:17. https://doi.org/10.1186/1751-0473-3-17
doi: 10.1186/1751-0473-3-17
pubmed: 19087314
pmcid: 2633005
Chowdhury MZI, Turin TC (2020) Variable selection strategies and its importance in clinical prediction modelling. Fam Med Community Health 8(1):e000262. https://doi.org/10.1136/fmch-2019-000262
doi: 10.1136/fmch-2019-000262
pubmed: 32148735
pmcid: 7032893
Carrick D, Haig C, Rauhalammi S, Ahmed N, Mordi I, McEntegart M et al (2015) Pathophysiology of LV remodeling in survivors of STEMI: inflammation, remote myocardium, and prognosis. JACC Cardiovasc Imaging 8(7):779–789. https://doi.org/10.1016/j.jcmg.2015.03.007
doi: 10.1016/j.jcmg.2015.03.007
pubmed: 26093923
pmcid: 4509710
van Assen M, van Dijk R, Kuijpers D, Vliegenthart R, Oudkerk M (2019) T1 reactivity as an imaging biomarker in myocardial tissue characterization discriminating normal, ischemic and infarcted myocardium. Int J Cardiovasc Imaging 35(7):1319–1325. https://doi.org/10.1007/s10554-019-01554-4
doi: 10.1007/s10554-019-01554-4
pubmed: 31093894
pmcid: 6598951
Garg P, Saunders LC, Swift AJ, Wild JM, Plein S (2018) Role of cardiac T1 mapping and extracellular volume in the assessment of myocardial infarction. Anatol J Cardiol 19(6):404–411. https://doi.org/10.14744/AnatolJCardiol.2018.39586
doi: 10.14744/AnatolJCardiol.2018.39586
pubmed: 29638222
pmcid: 5998858
Vo HQ, Marwick TH, Negishi K (2020) Pooled summary of native T1 value and extracellular volume with MOLLI variant sequences in normal subjects and patients with cardiovascular disease. Int J Cardiovasc Imaging 36(2):325–336. https://doi.org/10.1007/s10554-019-01717-3
doi: 10.1007/s10554-019-01717-3
pubmed: 31686277
Podlesnikar T, Pizarro G, Fernandez-Jimenez R, Montero-Cabezas JM, Greif N, Sanchez-Gonzalez J et al (2020) Left ventricular functional recovery of infarcted and remote myocardium after ST-segment elevation myocardial infarction (METOCARD-CNIC randomized clinical trial substudy). J Cardiovasc Magn Reson 22(1):44. https://doi.org/10.1186/s12968-020-00638-8
doi: 10.1186/s12968-020-00638-8
pubmed: 32522198
pmcid: 7288440
Reinstadler SJ, Stiermaier T, Liebetrau J, Fuernau G, Eitel C, de Waha S et al (2018) Prognostic significance of remote myocardium alterations assessed by quantitative noncontrast T1 mapping in ST-segment elevation myocardial infarction. JACC Cardiovasc Imaging 11(3):411–419. https://doi.org/10.1016/j.jcmg.2017.03.015
doi: 10.1016/j.jcmg.2017.03.015
pubmed: 28624398
Choi EY, Hwang SH, Yoon YW, Park CH, Paek MY, Greiser A et al (2013) Correction with blood T1 is essential when measuring post-contrast myocardial T1 value in patients with acute myocardial infarction. J Cardiovasc Magn Reson 15:11. https://doi.org/10.1186/1532-429X-15-11
doi: 10.1186/1532-429X-15-11
pubmed: 23331480
pmcid: 3564738
Chan W, Duffy SJ, White DA, Gao XM, Du XJ, Ellims AH et al (2012) Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion. JACC Cardiovasc Imaging 5(9):884–893. https://doi.org/10.1016/j.jcmg.2012.03.015
doi: 10.1016/j.jcmg.2012.03.015
pubmed: 22974800
Bulluck H, Dharmakumar R, Arai AE, Berry C, Hausenloy DJ (2018) Cardiovascular magnetic resonance in acute ST-segment-elevation myocardial infarction: recent advances, controversies, and future directions. Circulation 137(18):1949–1964. https://doi.org/10.1161/CIRCULATIONAHA.117.030693
doi: 10.1161/CIRCULATIONAHA.117.030693
pubmed: 29712696
pmcid: 5933067
Carberry J, Carrick D, Haig C, Rauhalammi SM, Ahmed N, Mordi I et al (2016) Remote zone extracellular volume and left ventricular remodeling in survivors of ST-elevation myocardial infarction. Hypertension 68(2):385–391. https://doi.org/10.1161/HYPERTENSIONAHA.116.07222
doi: 10.1161/HYPERTENSIONAHA.116.07222
pubmed: 27354423
Ishiyama M, Kurita T, Nakamura S, Omori T, Nakamori S, Ishida M et al (2021) Prognostic importance of acute phase extracellular volume evaluated by cardiac magnetic resonance imaging for patients with acute myocardial infarction. Int J Cardiovasc Imaging. https://doi.org/10.1007/s10554-021-02321-0
doi: 10.1007/s10554-021-02321-0
pubmed: 34191203
Bulluck H, Rosmini S, Abdel-Gadir A, White SK, Bhuva AN, Treibel TA et al (2016) Automated extracellular volume fraction mapping provides insights into the pathophysiology of left ventricular remodeling post-reperfused ST-elevation myocardial infarction. J Am Heart Assoc. https://doi.org/10.1161/JAHA.116.003555
doi: 10.1161/JAHA.116.003555
pubmed: 27402229
pmcid: 5015393
Moulin K, Viallon M, Romero W, Chazot A, Mewton N, Isaaz K et al (2020) MRI of reperfused acute myocardial infarction edema: ADC quantification versus T1 and T2 mapping. Radiology 295(3):542–549. https://doi.org/10.1148/radiol.2020192186
doi: 10.1148/radiol.2020192186
pubmed: 32208095
Monmeneu JV, Bodi V, Sanchis J, Lopez-Lereu MP, Mainar L, Nunez J et al (2009) Cardiac magnetic resonance evaluation of edema after ST-elevation acute myocardial infarction. Rev Esp Cardiol 62(8):858–866. https://doi.org/10.1016/s1885-5857(09)72650-7
doi: 10.1016/s1885-5857(09)72650-7
pubmed: 19706241
Bohnen S, Radunski UK, Lund GK, Kandolf R, Stehning C, Schnackenburg B et al (2015) Performance of t1 and t2 mapping cardiovascular magnetic resonance to detect active myocarditis in patients with recent-onset heart failure. Circ Cardiovasc Imaging. https://doi.org/10.1161/CIRCIMAGING.114.003073
doi: 10.1161/CIRCIMAGING.114.003073
pubmed: 26015267