SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses.
Journal
NPJ vaccines
ISSN: 2059-0105
Titre abrégé: NPJ Vaccines
Pays: England
ID NLM: 101699863
Informations de publication
Date de publication:
13 Dec 2021
13 Dec 2021
Historique:
received:
12
05
2021
accepted:
09
11
2021
entrez:
14
12
2021
pubmed:
15
12
2021
medline:
15
12
2021
Statut:
epublish
Résumé
The emergence of variants of concern, some with reduced susceptibility to COVID-19 vaccines underscores consideration for the understanding of vaccine design that optimizes induction of effective cellular and humoral immune responses. We assessed a SARS-CoV-2 spike-ferritin nanoparticle (SpFN) immunogen paired with two distinct adjuvants, Alhydrogel
Identifiants
pubmed: 34903722
doi: 10.1038/s41541-021-00414-4
pii: 10.1038/s41541-021-00414-4
pmc: PMC8668928
doi:
Types de publication
Journal Article
Langues
eng
Pagination
151Subventions
Organisme : NIAID NIH HHS
ID : R01 AI154619
Pays : United States
Organisme : U.S. Department of Defense (United States Department of Defense)
ID : W81XWH-18-2-0040
Organisme : United States Department of Defense | Uniformed Services University of the Health Sciences (Uniformed Services University)
ID : PED-86-10342
Informations de copyright
© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.
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