Beneficial and detrimental functions of microglia during viral encephalitis.
CNS infection
antiviral defence
brain immune response
cellular crosstalk
microglia
Journal
Trends in neurosciences
ISSN: 1878-108X
Titre abrégé: Trends Neurosci
Pays: England
ID NLM: 7808616
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
02
07
2021
revised:
28
10
2021
accepted:
16
11
2021
pubmed:
16
12
2021
medline:
8
4
2022
entrez:
15
12
2021
Statut:
ppublish
Résumé
Microglia are resident immune cells of the central nervous system (CNS) with multiple functions in health and disease. Their response during encephalitis depends on whether inflammation is triggered in a sterile or infectious manner, and in the latter case on the type of the infecting pathogen. Even though recent technological innovations advanced the understanding of the broad spectrum of microglia responses during viral encephalitis (VE), it is not entirely clear which microglia gene expression profiles are associated with antiviral and detrimental activities. Here, we review novel approaches to study microglia and the latest concepts of their function in VE. Improved understanding of microglial functions will be essential for the development of new therapeutic interventions for VE.
Identifiants
pubmed: 34906391
pii: S0166-2236(21)00233-2
doi: 10.1016/j.tins.2021.11.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-170Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests in relation to this work.