Neuroprotective potential of flavonoid rich Ascophyllum nodosum (FRAN) fraction from the brown seaweed on an Aβ

Alzheimer Disease / drug therapy Amyloid beta-Peptides Animals Ascophyllum Disease Models, Animal Drosophila Drosophila melanogaster Flavonoids / pharmacology Neuroprotection Peptide Fragments Seaweed
Alzheimer's disease Drosophila melanogaster Flavonoid-rich ascophyllum nodosum Mitochondrial Oxidative stress

Journal

Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794

Informations de publication

Date de publication:
Jan 2022
Historique:
received: 20 02 2021
revised: 24 11 2021
accepted: 29 11 2021
pubmed: 16 12 2021
medline: 18 1 2022
entrez: 15 12 2021
Statut: ppublish

Résumé

In Alzheimer Disease (AD) pathogenesis, aggregation of Aβ This study aimed to investigate the neuroprotective role of FRAN in the Aβ Drosophila stocks: OregonR In order to determine the most effective lethal dose of FRAN extract concentration 1, 2, 5, 10 mg/ml were screened using OregonR In conclusion, FRAN extract rich in flavonoids as having largest neuroprotective activity against Aβ

Sections du résumé

BACKGROUND BACKGROUND
In Alzheimer Disease (AD) pathogenesis, aggregation of Aβ
PURPOSE OBJECTIVE
This study aimed to investigate the neuroprotective role of FRAN in the Aβ
METHODS METHODS
Drosophila stocks: OregonR
RESULTS RESULTS
In order to determine the most effective lethal dose of FRAN extract concentration 1, 2, 5, 10 mg/ml were screened using OregonR
CONCLUSION CONCLUSIONS
In conclusion, FRAN extract rich in flavonoids as having largest neuroprotective activity against Aβ

Identifiants

DOI: 10.1016/j.phymed.2021.153872 PMID: 34906893
pubmed: 34906893
pii: S0944-7113(21)00412-8
doi: 10.1016/j.phymed.2021.153872
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Flavonoids 0
Peptide Fragments 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

153872

Informations de copyright

Copyright © 2021. Published by Elsevier GmbH.

Auteurs

Brijesh Singh Chauhan (BS)

Cell and Neurobiology Laboratory, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

Rohit Kumar (R)

Cell and Neurobiology Laboratory, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

Pradeep Kumar (P)

Cell and Neurobiology Laboratory, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

Prabhat Kumar (P)

Cell and Neurobiology Laboratory, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.

Saket Sinha (S)

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India.

Sunil Kumar Mishra (SK)

Department of Pharmaceutical Engineering and Technology, Indian Institute of Technology, Banaras Hindu University, Varanasi 221005, India.

Pradeep Kumar (P)

Department of Botany, MMV, Banaras Hindu University, Varanasi 221005, India.

Kavindra Nath Tiwari (KN)

Department of Botany, MMV, Banaras Hindu University, Varanasi 221005, India.

Alan T Critchley (AT)

Verschuren Centre for Sustainability in Energy and the Environment, Cape Breton University, Sydney, Nova Scotia, B1P 6L2 Canada.

Balakrishnan Prithiviraj (B)

Department of Plant, Food and Environmental Sciences, Faculty of Agriculture, Dalhousie University, Truro, Nova Scotia, B2N 5E3 Canada.

Saripella Srikrishna (S)

Cell and Neurobiology Laboratory, Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India. Electronic address: skrishna@bhu.ac.in.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Eucaryotes › Animaux › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Eucaryotes › Straménopiles › Phaeophyta › Ascophyllum › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Fragments peptidiques › Neuroprotective potential of flavonoid rich...
questionsmedicales.fr › Stades d'organismes › Algue marine › Neuroprotective potential of flavonoid rich...