Asymmetric hydrogenation for the synthesis of 2-substituted chiral morpholines.
Journal
Chemical science
ISSN: 2041-6520
Titre abrégé: Chem Sci
Pays: England
ID NLM: 101545951
Informations de publication
Date de publication:
24 Nov 2021
24 Nov 2021
Historique:
received:
05
08
2021
accepted:
26
10
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
16
12
2021
Statut:
epublish
Résumé
Asymmetric hydrogenation of unsaturated morpholines has been developed by using a bisphosphine-rhodium catalyst bearing a large bite angle. With this approach, a variety of 2-substituted chiral morpholines could be obtained in quantitative yields and with excellent enantioselectivities (up to 99% ee). The hydrogenated products could be transformed into key intermediates for bioactive compounds.
Identifiants
pubmed: 34909146
doi: 10.1039/d1sc04288b
pii: d1sc04288b
pmc: PMC8612400
doi:
Types de publication
Journal Article
Langues
eng
Pagination
15061-15066Informations de copyright
This journal is © The Royal Society of Chemistry.
Déclaration de conflit d'intérêts
There are no conflicts to declare.
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