The role of protein oxidation in the development of diabetic microvascular complications.
Diabetes mellitus
microvascular complications
neuropathy
retinopathy
thiol-disulfide
Journal
Northern clinics of Istanbul
ISSN: 2536-4553
Titre abrégé: North Clin Istanb
Pays: Turkey
ID NLM: 101684520
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
10
2020
accepted:
28
01
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
16
12
2021
Statut:
epublish
Résumé
The role of protein oxidation in the development of diabetic microvascular complications was investigated. In total, 266 participants were split into five groups: Group 1; diabetes mellitus for at least 10 years without any complications, Group 2; diabetic nephropathy, Group 3; diabetic neuropathy, Group 4; diabetic retinopathy, and Group 5; control group. Thiol, disulfide, ferroxidase, and ischemia-modified albumin (IMA) levels were analyzed in the serum. Native thiol, total thiol, and native thiol/total thiol were lower in Group 4 than Groups 1, 3, and 5 (p<0.001). However, disulfide/native thiol and disulfide/total thiol were higher in Group 4 than all other groups (p<0.001). IMA was higher in Groups 3 and 4 than all other groups (p<0.001). Ferroxidase was lower in Groups 3 and 4 than Group 2 (p<0.001). Thiol-disulfide homeostasis impairment in favor of disulfide may have a function in the progress of diabetic retinopathy. Furthermore, the disruptions of IMA and ferroxidase levels involve in the development of diabetic retinopathy and neuropathy.
Identifiants
pubmed: 34909589
doi: 10.14744/nci.2021.33341
pii: NCI-8-500
pmc: PMC8630725
doi:
Types de publication
Journal Article
Langues
eng
Pagination
500-506Informations de copyright
Copyright: © 2021 by Istanbul Northern Anatolian Association of Public Hospitals.
Déclaration de conflit d'intérêts
Conflict of Interest: No conflict of interest was declared by the authors.
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