Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: Fabrication, characterization and comparative
Carbopol
Diabetic wound healing
Low-energy emulsification
Nanoemulgel
Naringenin
Tocotrienols-rich fraction
Journal
Current research in pharmacology and drug discovery
ISSN: 2590-2571
Titre abrégé: Curr Res Pharmacol Drug Discov
Pays: Netherlands
ID NLM: 9918300982506676
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
12
2020
revised:
20
02
2021
accepted:
22
02
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
16
12
2021
Statut:
epublish
Résumé
The present research had been attempted to formulate and characterize tocotrienols-rich naringenin nanoemulgel for topical application in chronic wound conditions associated with diabetes. In due course, different phases of the nanoemulsion were chosen based on the solubility study, where combination of Capryol 90 and tocotrienols, Solutol HS15, and Transcutol P were selected as oil, surfactant, and cosurfactant, respectively. The nanoemulsions were formulated using the spontaneous emulsification method. Subsequently, Carbopols were incorporated to develop corresponding nanoemulgels of the optimized nanoemulsions. Thermodynamically stable optimized nanoemulgels were evaluated for their globule size, polydispersity index (PDI), surface charge, viscosity, mucoadhesive property, spreadability,
Identifiants
pubmed: 34909654
doi: 10.1016/j.crphar.2021.100019
pii: S2590-2571(21)00006-7
pmc: PMC8663980
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100019Informations de copyright
© 2021 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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