Lipid Droplet Proteins in Acne Skin: A Sound Target for the Maintenance of Low Comedogenic Sebum and Acne-Prone Skin Health.
FFA, free fatty acid
LD, lipid droplet
SMFE, Silybum marianum fruit extract
TG, triglyceride
Journal
JID innovations : skin science from molecules to population health
ISSN: 2667-0267
Titre abrégé: JID Innov
Pays: Netherlands
ID NLM: 101776173
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
01
02
2021
revised:
02
06
2021
accepted:
02
06
2021
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
16
12
2021
Statut:
epublish
Résumé
In adipocytes and sebocytes, lipid droplet proteins control the storage of lipids in organized droplets and their release on demand. The contribution of lipid droplet proteins to the pathogenesis of acne is plausible because they control the levels of comedogenic free fatty acids. The expression of two lipid droplet proteins, CIDEA and PLIN2, was analyzed in the skin of patients with acne by immunohistochemistry and western blotting. The design of clinical protocols allowed correlating the expression of CIDEA and PLIN2 with both comedogenesis and the release of free fatty acids. Both proteins were detected by immunohistochemistry in the sebaceous glands of patients with acne, with a disturbed expression pattern of PLIN2 compared with that in the controls. Higher levels of PLIN2 and CIDEA, as detected by western blotting in the infundibulum, significantly correlated with lower ongoing comedogenesis over 48 weeks of
Identifiants
pubmed: 34909752
doi: 10.1016/j.xjidi.2021.100057
pii: S2667-0267(21)00058-8
pmc: PMC8659390
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100057Informations de copyright
© 2021 The Authors.
Références
J Biol Chem. 2011 May 6;286(18):15707-15
pubmed: 21393244
Can J Biochem Physiol. 1959 Aug;37(8):911-7
pubmed: 13671378
Dermatology. 2003;206(1):11-6
pubmed: 12566800
J Eur Acad Dermatol Venereol. 2020 Feb;34(2):357-364
pubmed: 31465602
Br J Dermatol. 1972 Oct;87(4):327-32
pubmed: 4263289
Cold Spring Harb Protoc. 2010 Jun;2010(6):pdb.prot5439
pubmed: 20516177
Exp Cell Res. 2016 Jan 15;340(2):205-8
pubmed: 26571075
Exp Cell Res. 2015 Mar 1;332(1):146-55
pubmed: 25523620
J Eur Acad Dermatol Venereol. 2011 Jan;25(1):43-8
pubmed: 20456560
J Lipid Res. 2016 Nov;57(11):1976-1986
pubmed: 27009116
Exp Dermatol. 2020 Feb;29(2):168-176
pubmed: 31863492
Trends Cell Biol. 2016 Jul;26(7):535-546
pubmed: 26995697
Int J Biochem Cell Biol. 2010 Feb;42(2):181-5
pubmed: 19944183
Lipids Health Dis. 2017 Apr 28;16(1):83
pubmed: 28454542
Clin Cosmet Investig Dermatol. 2015 Jul 15;8:371-88
pubmed: 26203267
J Am Acad Dermatol. 1996 Oct;35(4):559-65
pubmed: 8859284
Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155
pubmed: 30523332
Arch Dermatol Res. 2016 Jan;308(1):1-6
pubmed: 26437897
ScientificWorldJournal. 2014;2014:462634
pubmed: 25177726
Nat Rev Mol Cell Biol. 2017 Nov;18(11):671-684
pubmed: 28852221
Semin Cell Dev Biol. 2012 Oct;23(8):928-36
pubmed: 22960253
Toxicol Sci. 2017 Dec 1;160(2):230-243
pubmed: 28973660
Br J Dermatol. 2005 Jun;152(6):1248-55
pubmed: 15948989
Mol Cell Biol. 2014 May;34(10):1827-38
pubmed: 24636991