TGFBR3L is an inhibin B co-receptor that regulates female fertility.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
17 Dec 2021
17 Dec 2021
Historique:
entrez:
15
12
2021
pubmed:
16
12
2021
medline:
16
12
2021
Statut:
ppublish
Résumé
Follicle-stimulating hormone (FSH), a key regulator of ovarian function, is often used in infertility treatment. Gonadal inhibins suppress FSH synthesis by pituitary gonadotrope cells. The TGFβ type III receptor, betaglycan, is required for inhibin A suppression of FSH. The inhibin B co-receptor was previously unknown. Here, we report that the gonadotrope-restricted transmembrane protein, TGFBR3L, is the elusive inhibin B co-receptor. TGFBR3L binds inhibin B but not other TGFβ family ligands. TGFBR3L knockdown or overexpression abrogates or confers inhibin B activity in cells. Female
Identifiants
pubmed: 34910520
doi: 10.1126/sciadv.abl4391
pmc: PMC8673766
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabl4391Subventions
Organisme : Medical Research Council
ID : MR/T012153/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK046943
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM058670
Pays : United States
Organisme : NIDDK NIH HHS
ID : R56 DK046943
Pays : United States
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