Interleukins in adipose tissue: Keeping the balance.

Adipocytes / metabolism Adipose Tissue / metabolism Humans Inflammation / metabolism Insulin Resistance Interleukins / metabolism
Adipose tissue Cytokine Insulin resistance Interleukins Obesity

Journal

Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844

Informations de publication

Date de publication:
15 02 2022
Historique:
received: 26 04 2021
revised: 01 12 2021
accepted: 08 12 2021
pubmed: 16 12 2021
medline: 5 4 2022
entrez: 15 12 2021
Statut: ppublish

Résumé

The role of the immune system is to defend the host and preserve the functionality in response to stress. This function is not limited to infection or injury as it also plays a role in the response to overnutrition. Indeed, low-grade chronic activation of the immune system associated with overnutrition may be deleterious, contributing importantly to diabetes and long-term complications, such as cardiovascular disorders. Increasing evidence shows that adipose tissue participates in the obesity-related inflammatory response and that interleukins are one of the key players, either as a pro-inflammatory response to the metabolic dysregulation or to restore homeostasis. The crosstalk between adipocytes and immune cells through some important interleukins and their role in metabolic disruption is the topic of this review.

Identifiants

DOI: 10.1016/j.mce.2021.111531 PMID: 34910978
pubmed: 34910978
pii: S0303-7207(21)00375-0
doi: 10.1016/j.mce.2021.111531
pii:
doi:

Substances chimiques

Interleukins 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

111531

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Barbara Antuna-Puente (B)

Infection Disease Division, Department of Medicine, Queen's University, Kingston, ON, Canada. Electronic address: bpap@queensu.ca.

Soraya Fellahi (S)

Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Département de Biochimie-pharmacologie-biologie Moléculaire-génétique Médicale, Créteil, France; Sorbonne Université-Inserm, Centre de Recherche Saint-Antoine UMR S_938, 75012, Paris Institut Hospitalo-Universitaire de Cardio-Métabolisme et Nutrition (ICAN), Paris, France.

Chloé McAvoy (C)

Unité de Recherche Clinique de L'Est Parisien (URC-Est), Hôpital Saint Antoine, Paris, France.

Bruno Fève (B)

Sorbonne Université-Inserm, Centre de Recherche Saint-Antoine UMR S_938, 75012, Paris Institut Hospitalo-Universitaire de Cardio-Métabolisme et Nutrition (ICAN), Paris, France; Assistance Publique- Hôpitaux de Paris -Hôpital Saint-Antoine, Service D'Endocrinologie-Diabétologie, Centre de Référence des Maladies Rares de L'Insulino-Sécrétion et de L'Insulino-Sensibilité (PRISIS), 75012, Paris, France.

Jean-Philippe Bastard (JP)

Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Henri Mondor, Département de Biochimie-pharmacologie-biologie Moléculaire-génétique Médicale, Créteil, France; FHU-SENEC, INSERM U955 and Université Paris Est (UPEC), UMR U955, Faculté de Santé, Créteil, France.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Adipocytes › Interleukins in adipose tissue: Keeping the balance.
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Interleukins in adipose tissue: Keeping the balance.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interleukins in adipose tissue: Keeping the balance.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Interleukins in adipose tissue: Keeping the balance.
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Interleukins in adipose tissue: Keeping the balance.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukins in adipose tissue: Keeping the balance.