Simultaneous positive patch test reactions to neomycin and low-molecular-weight heparins: possible cross-reaction?
allergic contact dermatitis
cross-reaction
drug reaction
low-molecular-weight heparins
neomycin
patch test
Journal
European journal of dermatology : EJD
ISSN: 1952-4013
Titre abrégé: Eur J Dermatol
Pays: France
ID NLM: 9206420
Informations de publication
Date de publication:
01 Dec 2021
01 Dec 2021
Historique:
pubmed:
17
12
2021
medline:
22
2
2022
entrez:
16
12
2021
Statut:
ppublish
Résumé
A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure. To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing. Patch testing of 12 individual controls with a history of neomycin contact allergy was performed. Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs. There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.
Sections du résumé
BACKGROUND
BACKGROUND
A patient received enoxaparin sodium subcutaneous injections for prophylaxis after surgery and developed inflammatory skin reactions on injection sites on Day 5 after the first administration. Patch test was performed with baseline series and low-molecular-weight heparins (LMWHs) at different concentrations and showed positive reactions to neomycin and LMWHs. Cross-reactivity between neomycin and LMWHs was suspected due to similar structure.
OBJECTIVES
OBJECTIVE
To establish the evidence of possible cross reaction between neomycin and LMWHs by patch testing.
MATERIALS & METHODS
METHODS
Patch testing of 12 individual controls with a history of neomycin contact allergy was performed.
RESULTS
RESULTS
Positive patch test reactions to enoxaparin sodium, tinzaparin sodium, and neomycin sulphate were reported in the patients. None of the controls reacted to LMWHs.
CONCLUSION
CONCLUSIONS
There was no proof of cross reaction between neomycin and LMWHs in this study, suggesting that the simultaneous reaction may be a coincidence. Since the number of individuals studied was low, allergy to LMWHs following injection in individuals with a history of neomycin allergy should be further investigated.
Identifiants
pubmed: 34911671
pii: ejd.2021.4164
doi: 10.1684/ejd.2021.4164
doi:
Substances chimiques
Anti-Bacterial Agents
0
Anticoagulants
0
Enoxaparin
0
enoxaparin sodium
8NZ41MIK1O
Neomycin
I16QD7X297
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM