The Effect of Bariatric Surgery on Circulating Levels of Oxidized Low-Density Lipoproteins Is Apparently Independent of Changes in Body Mass Index: A Systematic Review and Meta-Analysis.
Journal
Oxidative medicine and cellular longevity
ISSN: 1942-0994
Titre abrégé: Oxid Med Cell Longev
Pays: United States
ID NLM: 101479826
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
08
2021
revised:
10
10
2021
accepted:
15
11
2021
entrez:
16
12
2021
pubmed:
17
12
2021
medline:
1
3
2022
Statut:
epublish
Résumé
Obesity is related to dyslipidemia and increased circulating oxidated LDL (ox-LDL) concentrations that may predispose to atherosclerosis. Bariatric surgery may lower the risk of cardiovascular mortality. Elevated plasma ox-LDL has been associated with atherogenesis and atherosclerotic cardiovascular disease (ASCVD) events. The aim of this meta-analysis was to investigate the impact of bariatric surgery on proatherogenic circulating ox-LDL levels in patients with severe obesity. Four databases were systematically searched from inception to May 1, 2021. Also, to clarify the heterogeneity of studies with regard to treatment duration, research design, and the demographic features, a random-effects model and the generic inverse variance weighting approach were utilized. To determine the association with the estimated effect size, a random-effect meta-regression approach was performed. Finally, a meta-regression analysis was conducted to explore the influence of, respectively, baseline and changes in body mass index (BMI), baseline ox-LDL, and postsurgery follow-up period with the estimated effect size of surgery on ox-LDL levels. Meta-analysis of 11 studies including 470 subjects showed a significant decline in circulating ox-LDL following bariatric surgery (SMD: -0.971, 95% CI: -1.317, -0.626, Bariatric surgery in patients who had severe obesity causes a decrease of circulating ox-LDL that was apparently dependent in BMI changes.
Sections du résumé
BACKGROUND
BACKGROUND
Obesity is related to dyslipidemia and increased circulating oxidated LDL (ox-LDL) concentrations that may predispose to atherosclerosis. Bariatric surgery may lower the risk of cardiovascular mortality. Elevated plasma ox-LDL has been associated with atherogenesis and atherosclerotic cardiovascular disease (ASCVD) events. The aim of this meta-analysis was to investigate the impact of bariatric surgery on proatherogenic circulating ox-LDL levels in patients with severe obesity.
METHODS
METHODS
Four databases were systematically searched from inception to May 1, 2021. Also, to clarify the heterogeneity of studies with regard to treatment duration, research design, and the demographic features, a random-effects model and the generic inverse variance weighting approach were utilized. To determine the association with the estimated effect size, a random-effect meta-regression approach was performed. Finally, a meta-regression analysis was conducted to explore the influence of, respectively, baseline and changes in body mass index (BMI), baseline ox-LDL, and postsurgery follow-up period with the estimated effect size of surgery on ox-LDL levels.
RESULTS
RESULTS
Meta-analysis of 11 studies including 470 subjects showed a significant decline in circulating ox-LDL following bariatric surgery (SMD: -0.971, 95% CI: -1.317, -0.626,
CONCLUSION
CONCLUSIONS
Bariatric surgery in patients who had severe obesity causes a decrease of circulating ox-LDL that was apparently dependent in BMI changes.
Identifiants
pubmed: 34912496
doi: 10.1155/2021/4136071
pmc: PMC8668329
doi:
Substances chimiques
Lipoproteins, LDL
0
oxidized low density lipoprotein
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4136071Informations de copyright
Copyright © 2021 Tannaz Jamialahmadi et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest.
Références
Biometrics. 2000 Jun;56(2):455-63
pubmed: 10877304
Curr Opin Cardiol. 2011 Nov;26(6):555-61
pubmed: 21934498
Endocrinology. 2017 Dec 1;158(12):4139-4151
pubmed: 29040429
Pediatr Diabetes. 2010 Dec;11(8):552-5
pubmed: 20102528
Circulation. 2021 Apr 13;143(15):1468-1480
pubmed: 33813836
Am J Cardiol. 2003 Feb 6;91(3A):7A-11A
pubmed: 12645638
Atherosclerosis. 2014 Nov;237(1):108-16
pubmed: 25238217
J Clin Lipidol. 2021 Mar-Apr;15(2):320-331
pubmed: 33518459
Obes Rev. 2017 Jul;18(7):715-723
pubmed: 28489290
Am J Clin Nutr. 2006 Jan;83(1):30-5; quiz 181-2
pubmed: 16400046
Int J Obes (Lond). 2016 Feb;40(2):275-80
pubmed: 26315843
Circ Res. 2016 May 27;118(11):1786-807
pubmed: 27230642
JAMA Netw Open. 2019 Aug 2;2(8):e1910456
pubmed: 31469399
J Obes. 2013;2013:729515
pubmed: 24455214
Lipids Health Dis. 2018 Jun 20;17(1):145
pubmed: 29925393
Int J Obes (Lond). 2015 Aug;39(8):1254-63
pubmed: 25869607
PLoS One. 2018 May 29;13(5):e0198202
pubmed: 29813112
Br J Surg. 2020 Mar;107(4):432-442
pubmed: 31965568
BMJ. 2008 Apr 26;336(7650):924-6
pubmed: 18436948
Nat Rev Immunol. 2016 Aug;16(8):485-97
pubmed: 27346802
Int J Cardiol. 2015;189:47-55
pubmed: 25885871
Lancet. 2021 May 15;397(10287):1830-1841
pubmed: 33965067
Surg Obes Relat Dis. 2015 Jul-Aug;11(4):847-54
pubmed: 25862183
Am J Med. 2001 Feb 1;110(2):103-10
pubmed: 11165551
Curr Obes Rep. 2017 Sep;6(3):253-265
pubmed: 28780756
Atherosclerosis. 2014 May;234(1):200-5
pubmed: 24674904
BMC Med Res Methodol. 2005 Apr 20;5:13
pubmed: 15840177
Obes Surg. 2004 May;14(5):659-65
pubmed: 15186635
Clin Biochem. 2019 Jan;63:46-53
pubmed: 30342017
J Clin Lipidol. 2016 Jan-Feb;10(1):33-57
pubmed: 26892120
Pharmacol Res. 2015 Sep;99:329-36
pubmed: 26192349
Curr Obes Rep. 2021 Sep;10(3):263-273
pubmed: 33964008
Diabetes Care. 2008 Dec;31(12):2258-64
pubmed: 18835956
Curr Cardiol Rep. 2012 Dec;14(6):709-20
pubmed: 22965836
Eur J Clin Invest. 2020 Nov;50(11):e13320
pubmed: 32535887
Front Cardiovasc Med. 2020 Feb 25;7:22
pubmed: 32158768
Int J Obes (Lond). 2014 Nov;38(11):1410-5
pubmed: 24468701
Surg Endosc. 2021 Nov;35(11):6006-6012
pubmed: 33048234
Circulation. 2008 Apr 1;117(13):1658-67
pubmed: 18362231
Surg Obes Relat Dis. 2020 Oct;16(10):1419-1428
pubmed: 32694041
Can J Cardiol. 2017 Dec;33(12):1624-1632
pubmed: 29173602