Bone Marrow Adipocytes: A Critical Player in the Bone Marrow Microenvironment.
bone marrow adipocytes
bone marrow mesenchymal stromal cells
hematopoiesis
immune regulation
osteoclastogenesis
osteogenesis
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
09
2021
accepted:
29
10
2021
entrez:
16
12
2021
pubmed:
17
12
2021
medline:
17
12
2021
Statut:
epublish
Résumé
Recognized for nearly 100 years, bone marrow adipocytes (BMAs) form bone marrow niches that contain hematopoietic and bone cells, the roles of which have long been underestimated. Distinct from canonical white, brown, and beige adipocytes, BMAs derived from bone marrow mesenchymal stromal cells possess unique characteristics and functions. Recent single-cell sequencing studies have revealed the differentiation pathway, and seminal works support the tenet that BMAs are critical regulators in hematopoiesis, osteogenesis, and osteoclastogenesis. In this review, we discuss the origin and differentiation of BMAs, as well as the roles of BMAs in hematopoiesis, osteogenesis, osteoclastogenesis, and immune regulation. Overall, BMAs represent a novel target for bone marrow-related diseases, including osteoporosis and leukemia.
Identifiants
pubmed: 34912805
doi: 10.3389/fcell.2021.770705
pii: 770705
pmc: PMC8667222
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
770705Informations de copyright
Copyright © 2021 Wang, Zhang, Wang, Chen and Su.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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