Reporting The Effects of Exposure to Monosodium Glutamate on The Regulatory Peptides of The Hypothalamic-Pituitary-Gonadal Axis.
Hormones
Neuropeptides
Neurotrophic Factors
Reproduction
Sodium Glutamate
Journal
International journal of fertility & sterility
ISSN: 2008-076X
Titre abrégé: Int J Fertil Steril
Pays: Iran
ID NLM: 101487941
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
09
01
2021
accepted:
01
05
2021
entrez:
16
12
2021
pubmed:
17
12
2021
medline:
17
12
2021
Statut:
ppublish
Résumé
Monosodium glutamate (MSG) is a flavour enhancer that is used as a food additive (E621) in many parts of the world, especially in East Asian countries. However, in recent studies, it has been used as a neurotoxin because MSG is reported to cause neural degeneration in the hypothalamic arcuate of neonatal animals. The results of several studies show the negative effects of MSG injections on different parts of the hypothalamic-pituitary-gonadal (HPG) axis, in addition to its ability to inhibit secretion many reproductive neuropeptides, neurotrophic factors, and hormones, all of which play vital roles in the regulation of reproductive function. Oral administration or injection of large quantities of MSG into newborn animals results in a decrease in or overabundance of the production of many regulatory peptides of the male and female reproductive systems. In this review, we summarize the results of the most important studies that have examined the effect of oral consumption or injection of MSG on regulatory peptides of the HPG axis.
Identifiants
pubmed: 34913291
doi: 10.22074/IJFS.2021.522615.1072
pmc: PMC8530211
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
246-251Informations de copyright
Copyright© by Royan Institute. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Chem Immunol Allergy. 2005;89:135-148
pubmed: 16129960
J Ayub Med Coll Abbottabad. 2014 Jan-Mar;26(1):18-20
pubmed: 25358208
Am J Physiol Endocrinol Metab. 2013 Dec;305(12):E1512-20
pubmed: 24169048
Reprod Domest Anim. 2018 Sep;53 Suppl 2:62-65
pubmed: 30238654
Nutr Neurosci. 2004 Aug;7(4):241-5
pubmed: 15682651
Int J Exp Pathol. 2016 Feb;97(1):18-26
pubmed: 26799547
Neurosci Lett. 1988 Apr 22;87(1-2):114-21
pubmed: 2454423
J Physiol. 2000 Nov 15;529 Pt 1:57-68
pubmed: 11080251
Hum Fertil (Camb). 2018 Dec;21(4):248-254
pubmed: 28678563
Compr Rev Food Sci Food Saf. 2019 Jul;18(4):1111-1134
pubmed: 31920467
Cells Tissues Organs. 2005;179(4):192-201
pubmed: 16046865
Ultrastruct Pathol. 2019;43(4-5):170-183
pubmed: 31658851
Glycobiology. 2011 Apr;21(4):401-9
pubmed: 21030538
Physiol Behav. 1991 Nov;50(5):873-80
pubmed: 1805276
Ann Nutr Metab. 2018;73 Suppl 5:53-64
pubmed: 30508819
Peptides. 1986 Sep-Oct;7(5):749-53
pubmed: 2879275
Neurotoxicology. 1994 Fall;15(3):773-7
pubmed: 7854619
Biomed Pharmacother. 2019 Mar;111:503-516
pubmed: 30597304
Int J Neurosci. 2021 Aug;131(8):780-788
pubmed: 32303141
J Headache Pain. 2016;17:54
pubmed: 27189588
Acta Vet Hung. 2015 Mar;63(1):125-39
pubmed: 25655420
Gen Physiol Biophys. 2009;28 Spec No:149-54
pubmed: 19893093
Biomed Pharmacother. 2006 Feb;60(2):86-91
pubmed: 16488110
Basic Clin Pharmacol Toxicol. 2011 Jun;108(6):406-13
pubmed: 21205225
Neuroscience. 2019 Aug 10;413:264-278
pubmed: 31254543
Bratisl Lek Listy. 2006;107(5):185-91
pubmed: 16913079
Endocrinology. 2003 Sep;144(9):3842-7
pubmed: 12933656
Exp Brain Res. 1989;76(2):343-68
pubmed: 2569986
Bull Exp Biol Med. 2005 Jun;139(6):711-4
pubmed: 16224589
BMC Neurosci. 2006 Jun 15;7:49
pubmed: 16776830
Reprod Biol Endocrinol. 2012 Dec 05;10:105
pubmed: 23216967
Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):15043-8
pubmed: 9844012
Endocrinology. 2006 Mar;147(3):1556-63
pubmed: 16339210
EXCLI J. 2018 Mar 19;17:273-278
pubmed: 29743864
Regul Pept. 1998 Sep 25;75-76:441-7
pubmed: 9802441
Ross Fiziol Zh Im I M Sechenova. 2005 May;91(5):574-80
pubmed: 16117177
Neuroendocrinology. 2003 Nov;78(5):270-9
pubmed: 14657608
Toxicol Lett. 2019 Feb;301:11-16
pubmed: 30394305
J Clin Endocrinol Metab. 1996 Jan;81(1):184-91
pubmed: 8550750
J Biosci. 2018 Sep;43(4):569-574
pubmed: 30207304
Cell Metab. 2010 Apr 7;11(4):286-97
pubmed: 20374961
J Endocrinol. 2007 Jul;194(1):153-60
pubmed: 17592029
Environ Toxicol. 2018 Feb;33(2):198-208
pubmed: 29119727
Iran J Basic Med Sci. 2019 Dec;22(12):1462-1467
pubmed: 32133065
Psychopharmacology (Berl). 1989;97(3):383-7
pubmed: 2497489
Neuroreport. 1995 Dec 15;6(18):2450-2
pubmed: 8741739
Pathophysiology. 2017 Dec;24(4):243-249
pubmed: 28943112
J Microsc Ultrastruct. 2018 Apr-Jun;6(2):105-115
pubmed: 30221135
J Neuroendocrinol. 2015 Mar;27(3):187-97
pubmed: 25582792
Brain Res. 1997 Feb 7;747(2):195-206
pubmed: 9045994
Reprod Biol Endocrinol. 2014 Feb 06;12:15
pubmed: 24502529
Brain Res. 2001 Mar 16;894(2):301-6
pubmed: 11251205
Front Neuroendocrinol. 2011 Jan;32(1):1-9
pubmed: 20558195
Reprod Fertil Dev. 2016 Oct;28(12):1904-1915
pubmed: 26108912
BMC Res Notes. 2019 Sep 18;12(1):593
pubmed: 31533812
Endocrinology. 1998 Nov;139(11):4483-8
pubmed: 9794456
Nutr Neurosci. 2015;18(8):376-82
pubmed: 26230366
Neuroendocrinology. 2005;81(1):19-30
pubmed: 15809509
Mol Pharmacol. 1995 Nov;48(5):790-7
pubmed: 7476908
Indian J Biochem Biophys. 2006 Feb;43(1):20-4
pubmed: 16955747
Neuroscience. 2010 Mar 17;166(2):680-97
pubmed: 20038444
Anat Rec. 1994 Oct;240(2):255-60
pubmed: 7992892
Am J Physiol Regul Integr Comp Physiol. 2008 Mar;294(3):R775-83
pubmed: 18094070
Neuroendocrinology. 1998 Jun;67(6):412-20
pubmed: 9662721
Endocrinology. 1999 Aug;140(8):3643-52
pubmed: 10433222
Acta Med Acad. 2014;43(1):3-9
pubmed: 24893633