Cardiovascular Effects of Autologous Bone Marrow-Derived Mesenchymal Stromal Cell Therapy With Early Tacrolimus Withdrawal in Renal Transplant Recipients: An Analysis of the Randomized TRITON Study.
immunosuppression
left ventricular diastolic function
left ventricular hypertrophy
mesenchymal stem cells
renal transplantation
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
21 12 2021
21 12 2021
Historique:
pubmed:
17
12
2021
medline:
23
3
2022
entrez:
16
12
2021
Statut:
ppublish
Résumé
Background After renal transplantation, there is a need of immunosuppressive regimens that effectively prevent allograft rejection while minimizing cardiovascular complications. This substudy of the TRITON trial evaluated the cardiovascular effects of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in renal transplant recipients. Methods and Results Renal transplant recipients were randomized to MSC therapy, infused at weeks 6 and 7 after transplantation, with withdrawal at week 8 of tacrolimus or standard tacrolimus dose. Fifty-four patients (MSC group=27; control group=27) underwent transthoracic echocardiography at weeks 4 and 24 after transplantation and were included in this substudy. Changes in clinical and echocardiographic variables were compared. The MSC group showed a benefit in blood pressure control, assessed by a significant interaction between changes in diastolic blood pressure and the treatment group (
Identifiants
pubmed: 34913362
doi: 10.1161/JAHA.121.023300
pmc: PMC9075245
doi:
Substances chimiques
Tacrolimus
WM0HAQ4WNM
Banques de données
ClinicalTrials.gov
['NCT03398681']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e023300Références
Cochrane Database Syst Rev. 2017 Jul 21;7:CD006750
pubmed: 28730648
Eur Heart J. 2008 Nov;29(22):2742-50
pubmed: 18790727
J Am Soc Nephrol. 2005 Oct;16(10):3015-26
pubmed: 16120819
Am J Transplant. 2021 Sep;21(9):3055-3065
pubmed: 33565206
Transplant Proc. 2005 Mar;37(2):1039-43
pubmed: 15848616
Stem Cells Dev. 2015 Oct 15;24(20):2391-402
pubmed: 26076727
Stem Cells Transl Med. 2013 Feb;2(2):107-11
pubmed: 23349326
Eur Heart J Cardiovasc Imaging. 2016 Dec;17(12):1321-1360
pubmed: 27422899
Circulation. 2000 Oct 10;102(15):1788-94
pubmed: 11023933
Stem Cells Transl Med. 2018 Dec;7(12):857-866
pubmed: 30255989
Sci Transl Med. 2017 Nov 15;9(416):
pubmed: 29141887
Ultrastruct Pathol. 2017 Jan-Feb;41(1):36-50
pubmed: 28029272
Transpl Int. 2011 Jan;24(1):30-42
pubmed: 20642495
Clin J Am Soc Nephrol. 2011 Feb;6(2):412-22
pubmed: 20930086
Cell Transplant. 2015;24(10):2041-53
pubmed: 25420012
PLoS One. 2013 Nov 04;8(11):e78464
pubmed: 24223811
Kidney Int. 2019 Mar;95(3):693-707
pubmed: 30528263
Circ Res. 2010 Oct 1;107(7):913-22
pubmed: 20671238
Am J Physiol Renal Physiol. 2001 Jun;280(6):F964-71
pubmed: 11352835
Kidney Int. 1998 Jan;53(1):217-22
pubmed: 9453022
N Engl J Med. 1990 Sep 13;323(11):748-50
pubmed: 2388672
J Am Soc Echocardiogr. 2005 Dec;18(12):1440-63
pubmed: 16376782
Circulation. 2000 Oct 31;102(18):2269-75
pubmed: 11056104
Am J Transplant. 2005 Nov;5(11):2725-31
pubmed: 16212633
Am J Transplant. 2020 Oct;20(10):2905-2915
pubmed: 32277568
J Hypertens. 2006 Aug;24(8):1663-70
pubmed: 16877971
Circulation. 2012 Feb 7;125(5):708-20
pubmed: 22207715
Lancet. 2011 Oct 15;378(9800):1419-27
pubmed: 22000138
Transplantation. 2002 Dec 15;74(11):1580-7
pubmed: 12490792
Circulation. 2000 May 23;101(20):2431-7
pubmed: 10821822
Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1814-9
pubmed: 19717730
Circ Res. 1999 Apr 2;84(6):729-34
pubmed: 10189361
Circulation. 2021 Mar 16;143(11):1157-1172
pubmed: 33720773
Am J Kidney Dis. 2007 Jul;50(1):133-42
pubmed: 17591533
JACC Heart Fail. 2021 Apr;9(4):301-313
pubmed: 33795116
J Am Soc Echocardiogr. 2010 Jul;23(7):685-713; quiz 786-8
pubmed: 20620859
J Am Soc Echocardiogr. 2017 Apr;30(4):372-392
pubmed: 28385280
Ann Intern Med. 2009 May 5;150(9):604-12
pubmed: 19414839
Blood. 2005 Feb 15;105(4):1815-22
pubmed: 15494428
Circulation. 2003 Apr 1;107(12):1664-70
pubmed: 12668503
Transplant Proc. 2014 Nov;46(9):3194-8
pubmed: 25420857
Regen Med. 2007 Jan;2(1):63-8
pubmed: 17465776
J Am Soc Nephrol. 2003 Feb;14(2):462-8
pubmed: 12538748
Transplantation. 2008 Nov 27;86(10):1395-400
pubmed: 19034009
Transplant Proc. 2014 Oct;46(8):2719-23
pubmed: 25380902
Circulation. 2004 Jun 22;109(24):3050-5
pubmed: 15184287
Am J Cardiol. 1986 Feb 15;57(6):450-8
pubmed: 2936235
Transplantation. 2012 Oct 15;94(7):721-8
pubmed: 22955227
J Am Soc Nephrol. 2020 Dec;31(12):2887-2899
pubmed: 32908001